Routine Immunization Regimen of Three I.M. Hepatitis B Vaccine Doses, by
product/age:
Recombivax HB®
Birth* to 10 years: Initial dose 0.25 mL**; repeat in 1 month and 6 months
11-19 years: Initial dose 0.5 mL; repeat in 1 month and 6 months
greater than or equal to 20 years: Initial dose 1 mL; repeat in 1 month and
6 months
Energix-B®
Birth* to 10 years: Initial dose 0.5 mL; repeat in 1 month and 6 months
11-19 y: Initial dose 1 mL; repeat in 1 month and 6 months
greater than or equal to 20 y: Initial dose 1 mL; repeat in 1 month and 6
months
Dialysis or immunocompromised patients: Initial dose 2 mL***; repeat in 1
month and 6 months
*Infants born of HBsAg, negative mothers
**0.5 mL of the 5 mcg/0.5 mL (adolescent/high-risk infant) product or 0.5 mL
of the 25 mcg/0.5 mL pediatric formulation
***Two 1 mL doses given at different sites.
Postexposure prophylaxis recommended dosage for infants born to
HBsAg-Positive mothers, by product/age:
Engerix-B® (pediatric product dose 10 mcg/0.5
mL):
Give 0.5 mL within 7 days. Alternately, the first dose may be given at birth
at the same time as HBIG, but give in the opposite anterolateral thigh. This may
better ensure vaccine absorption.
Repeat 0.5 mL at 1 month and 6 months.
Recombivax HB® (high-risk infant product dose 5
mcg/0.5 mL):
Give 0.25 mL within 7 days, or 0.5 mL of the pediatric product (0.25 mcg/0.5
mL). Alternately, the first dose may be given at birth at the same time as HBIG,
but give in the opposite anterolateral thigh. This may better ensure vaccine
absorption.
Repeat 0.25 mL at 1 month and 6 months, or with 0.5 mL if using the pediatric
product (0.25 mcg/0.5 mL)
Hepatitis B immune globulin:
Give 0.5 mL at birth
Note: An alternate regimen is administration of the vaccine at birth,
within 7 days of birth, and 1, 2, and 12 months later.
Dialysis regimen: Use Recombivax HB® formulation (40
mcg/mL); initial: 40 mcg/mL, then at 1 and 6 months; revaccination: if
anti-HBs <10 mIU/mL greater than or equal to 1-2 months after 3rd
dose