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Pronunciation |
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(ha
loe PROE
jin) |
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U.S. Brand
Names |
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Halotex® |
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Generic
Available |
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No |
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Pharmacological Index |
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Antifungal Agent, Topical |
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|
Use |
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Topical treatment of tinea pedis (athlete's foot), tinea cruris (jock itch),
tinea corporis (ringworm), tinea manuum caused by Trichophyton rubrum,
Trichophyton tonsurans, Trichophyton mentagrophytes,
Microsporum canis, or Epidermophyton floccosum; topical treatment of
Malassezia furfur |
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Pregnancy Risk
Factor |
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B |
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Contraindications |
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Hypersensitivity to haloprogin or any component |
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|
Warnings/Precautions |
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Safety and efficacy have not been established in
children |
|
|
Adverse
Reactions |
|
<1%: Pruritus, folliculitis, vesicle formation, erythema, irritation,
burning sensation |
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Drug
Interactions |
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No data reported |
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Mechanism of
Action |
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Interferes with fungal DNA replication to inhibit yeast cell respiration and
disrupt its cell membrane |
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Pharmacodynamics/Kinetics |
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Absorption: Poorly through the skin (~11%)
Metabolism: To trichlorophenol
Elimination: In urine, 75% as unchanged drug |
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|
Usual Dosage |
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Topical: Children and Adults: Apply liberally twice daily for 2-3 weeks;
intertriginous areas may require up to 4 weeks of treatment |
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Mental Health: Effects
on Mental Status |
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None noted |
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|
Mental Health:
Effects on Psychiatric
Treatment |
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None noted |
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Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
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No information available to require special precautions |
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Dental Health:
Effects on Dental Treatment |
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No effects or complications reported |
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Patient
Information |
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Avoid contact with eyes; for external use only; improvement should occur
within 4 weeks; discontinue use if sensitization or irritation
occur |
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Nursing
Implications |
|
Avoid contact with eyes; for external use only; improvement should occur
within 4 weeks; discontinue use if sensitization or irritation
occur |
|
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Dosage Forms |
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Cream: 1% (15 g, 30 g)
Solution, topical: 1% with alcohol 75% (10 mL, 30 mL)
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