| Pronunciation |
 (gwye
FEN e sin & deks troe meth
OR fan) |
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| U.S. Brand Names |
| Benylin® Expectorant [OTC]; Cheracol® D [OTC]; Clear Tussin® 30; Contac® Cough Formula Liquid [OTC]; Diabetic Tussin DM®[OTC]; Extra Action Cough Syrup [OTC]; Fenesin™ DM; Genatuss DM®[OTC]; Glycotuss-dM®[OTC]; Guaifenex® DM; GuiaCough®[OTC]; Guiatuss-DM®[OTC]; Halotussin® DM [OTC]; Humibid® DM [OTC]; Iobid DM®; Kolephrin® GG/DM [OTC]; Monafed® DM; Muco-Fen-DM®; Mytussin® DM [OTC]; Naldecon® Senior DX [OTC]; Phanatuss® Cough Syrup [OTC]; Phenadex® Senior [OTC]; Respa-DM®; Rhinosyn-DMX®[OTC]; Robafen DM®[OTC]; Robitussin®-DM [OTC]; Safe Tussin® 30 [OTC]; Scot-Tussin® Senior Clear [OTC]; Siltussin DM®[OTC]; Synacol® CF [OTC]; Syracol-CF®[OTC]; Tolu-Sed® DM [OTC]; Tusibron-DM®[OTC]; Tuss-DM®[OTC]; Tussi-Organidin® DM NR; Uni-tussin® DM [OTC]; Vicks® 44E [OTC]; Vicks® Pediatric Formula 44E [OTC] |
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| Generic Available |
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Yes |
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| Synonyms |
| Dextromethorphan and Guaifenesin |
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| Pharmacological Index |
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Antitussive; Cough Preparation; Expectorant |
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| Use |
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Temporary control of cough due to minor throat and bronchial irritation |
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| Pregnancy Risk Factor |
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C |
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| Contraindications |
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Hypersensitivity to guaifenesin, dextromethorphan or any component |
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| Warnings/Precautions |
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Should not be used for persistent or chronic cough such as that occurring with smoking, asthma, chronic bronchitis, or emphysema or for cough associated with excessive phlegm |
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| Adverse Reactions |
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1% to 10%: Dermatologic: Rash Gastrointestinal: Nausea, vomiting |
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| Drug Interactions |
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No data reported |
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| Stability |
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Protect from light |
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| Mechanism of Action |
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Guaifenesin is thought to act as an expectorant by irritating the gastric mucosa and stimulating respiratory tract secretions, thereby increasing respiratory fluid volumes and decreasing phlegm viscosity Dextromethorphan is a chemical relative of morphine lacking narcotic properties except in overdose; controls cough by depressing the medullary cough center |
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| Pharmacodynamics/Kinetics |
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Refer to Dextromethorphan and Guaifenesin monographs |
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| Usual Dosage |
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Oral: Children >12 years and Adults: 5 mL every 4 hours or 10 mL every 6-8 hours not to exceed 40 mL/24 hours |
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| Dental Health: Local Anesthetic/Vasoconstrictor Precautions |
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No information available to require special precautions |
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| Dental Health: Effects on Dental Treatment |
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No effects or complications reported |
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| Patient Information |
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See individual agents. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to get pregnant. Consult prescriber if breast-feeding. |
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| Nursing Implications |
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Administer with a large quantity of fluid The "NR" in Tussi-Organidin® DM NR means "Newly Reformulated" |
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| Dosage Forms |
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Syrup: Benylin® Expectorant: Guaifenesin 100 mg and dextromethorphan hydrobromide 5 mg per 5 mL (118 mL, 236 mL) Cheracol® D, Clear Tussin® 30, Genatuss® DM, Mytussin® DM, Robitussin®-DM, Siltussin DM®, Tolu-Sed® DM, Tussi-Organidin® DM NR: Guaifenesin 100 mg and dextromethorphan hydrobromide 10 mg per 5 mL (5 mL, 10 mL, 120 mL, 240 mL, 360 mL, 480 mL, 3780 mL) Contac® Cough Formula Liquid: Guaifenesin 67 mg and dextromethorphan hydrobromide 10 mg per 5 mL (120 mL) Extra Action Cough Syrup, GuiaCough®, Guiatuss DM®, Halotussin® DM, Rhinosyn-DMX®, Tusibron-DM®, Uni Tussin® DM: Guaifenesin 100 mg and dextromethorphan hydrobromide 15 mg per 5 mL (120 mL, 240 mL, 480 mL) Kolephrin® GG/DM: Guaifenesin 150 mg and dextromethorphan hydrobromide 10 mg per 5 mL (120 mL) Naldecon® Senior DX: Guaifenesin 200 mg and dextromethorphan hydrobromide 15 mg per 5 mL (118 mL, 480 mL) Phanatuss®: Guaifenesin 85 mg and dextromethorphan hydrobromide 10 mg per 5 mL Vicks® 44E: Guaifenesin 66.7 mg and dextromethorphan hydrobromide 6.7 mg per 5 mL Tablet: Extended release Guaifenex DM®, Iobid DM®, Fenesin™ DM, Humibid® DM, Monafed® DM, Respa-DM®: Guaifenesin 600 mg and dextromethorphan hydrobromide 30 mg Glycotuss-dM®: Guaifenesin 100 mg and dextromethorphan hydrobromide 10 mg Queltuss®: Guaifenesin 100 mg and dextromethorphan hydrobromide 15 mg Syracol-CF®: Guaifenesin 200 mg and dextromethorphan hydrobromide 15 mg Tuss-DM®: Guaifenesin 200 mg and dextromethorphan hydrobromide 10 mg |
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