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Pronunciation |
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(gwye
FEN e sin, soo doe e FED rin,
& deks troe meth OR fan) |
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U.S. Brand
Names |
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Anatuss® DM [OTC]; Dimacol®
Caplets [OTC]; Rhinosyn-X® Liquid [OTC]; Ru-Tuss® Expectorant
[OTC]; Sudafed® Cold & Cough Liquid Caps
[OTC] |
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Generic
Available |
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Yes |
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Synonyms |
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Dextromethorphan, Guaifenesin, and Pseudoephedrine; Pseudoephedrine,
Dextromethorphan, and Guaifenesin |
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Pharmacological Index |
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Antitussive/Decongestant/Expectorant |
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Use |
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Temporarily relieves nasal congestion and controls cough due to minor throat
and bronchial irritation; helps loosen phlegm and thin bronchial secretions to
make coughs more productive |
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Warnings/Precautions |
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Research on chicken embryos exposed to concentrations of dextromethorphan
relative to those typically taken by humans has shown to cause birth defects and
fetal death; more study is needed, but it is suggested that pregnant women
should be advised not to use dextromethorphan-containing
medications |
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Adverse
Reactions |
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See individual agents |
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Drug
Interactions |
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See individual agents |
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Mechanism of
Action |
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See individual agents |
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Usual Dosage |
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Adults: Oral: 2 capsules (caplets) or 10 mL every 4
hours |
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Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
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Use with caution since pseudoephedrine is a sympathomimetic amine which could
interact with epinephrine to cause a pressor response |
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Dental Health:
Effects on Dental Treatment |
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Guaifenesin: No effects or complications reported
Pseudoephedrine: Up to 10% of patients could experience tachycardia,
palpitations, and dry mouth; use vasoconstrictor with caution
Dextromethorphan: No effects or complications reported |
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Dosage Forms |
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Caplets (Dimacol®): Guaifenesin 100 mg, pseudoephedrine
hydrochloride 30 mg, and dextromethorphan hydrobromide 10 mg
Capsule (Sudafed® Cold & Cough Liquid Caps):
Guaifenesin 100 mg, pseudoephedrine hydrochloride 30 mg, and dextromethorphan
hydrobromide 10 mg
Liquid (Anatuss® DM, Novahistine®
DMX Liquid, Rhinosyn-X® Liquid,
Ru-Tuss® Expectorant): Guaifenesin 100 mg, pseudoephedrine
hydrochloride 30 mg, and dextromethorphan hydrobromide 10 mg per 5 mL
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