Guaifenesin, Pseudoephedrine, and Codeine

Look Up > Drugs > Guaifenesin, Pseudoephedrine, and Codeine

	Pronunciation
	U.S. Brand Names
	Generic Available
	Synonyms
	Pharmacological Index
	Use
	Restrictions

	Pregnancy Risk Factor
	Usual Dosage
	Dental Health: Local Anesthetic/Vasoconstrictor Precautions
	Dental Health: Effects on Dental Treatment
	Patient Information
	Dosage Forms

Pronunciation

(gwye FEN e sin, soo doe e FED rin, & KOE deen)

U.S. Brand Names

Codafed® Expectorant; Cycofed® Pediatric; Decohistine® Expectorant; Deproist® Expectorant With Codeine; Dihistine® Expectorant; Guiatuss DAC®; Guiatussin® DAC; Halotussin® DAC; Isoclor® Expectorant; Mytussin® DAC; Nucofed®; Nucofed® Pediatric Expectorant; Nucotuss®; Phenhist® Expectorant; Robitussin®-DAC; Ryna-CX®; Tussar® SF Syrup

Generic Available

Yes

Synonyms

Codeine, Guaifenesin, and Pseudoephedrine; Pseudoephedrine, Guaifenesin, and Codeine

Pharmacological Index

Antitussive/Decongestant/Expectorant

Use

Temporarily relieves nasal congestion and controls cough due to minor throat and bronchial irritation; helps loosen phlegm and thin bronchial secretions to make coughs more productive

Restrictions

C-III; C-V

Pregnancy Risk Factor

Usual Dosage

Oral:

Children >12 years and Adults: 10 mL every 4 hours, not to exceed 40 mL/24 hours

Dental Health: Local Anesthetic/Vasoconstrictor Precautions

Use with caution since pseudoephedrine is a sympathomimetic amine which could interact with epinephrine to cause a pressor response

Dental Health: Effects on Dental Treatment

Codeine: <1%: Dry mouth

Guaifenesin: No effects or complications reported

Pseudoephedrine: Up to 10% of patients could experience tachycardia, palpitations, and dry mouth; use vasoconstrictor with caution

Patient Information

See individual agents. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to get pregnant. Consult prescriber if breast-feeding.

Dosage Forms

Liquid:

C-III: Nucofed®, Nucotuss®: Guaifenesin 200 mg, pseudoephedrine hydrochloride 60 mg, and codeine phosphate 20 mg per 5 mL (480 mL)

C-V: Codafed® Expectorant, Decohistine® Expectorant, Deproist® Expectorant with Codeine, Dihistine® Expectorant, Guiatuss DAC®, Guiatussin® DAC, Halotussin® DAC, Isoclor® Expectorant, Mytussin® DAC, Nucofed® Pediatric Expectorant, Phenhist® Expectorant, Robitussin®-DAC, Ryna-CX®, Tussar® SF: Guaifenesin 100 mg, pseudoephedrine hydrochloride 30 mg, and codeine phosphate 10 mg per 5 mL (120 mL, 480 mL, 4000 mL)