Yes

Laxative; Ophthalmic Agent, Miscellaneous

Constipation; reduction of intraocular pressure; reduction of corneal edema; glycerin has been administered orally to reduce intracranial pressure

C

>10%:

Central nervous system: Headache

Gastrointestinal: Nausea, vomiting

1% to 10%:

Central nervous system: Confusion, dizziness

Endocrine: Polydipsia

Gastrointestinal: Diarrhea, dry mouth

<1%:

Cardiovascular: Arrhythmias

Endocrine & metabolic: Hyperglycemia

Gastrointestinal: Tenesmus, rectal irritation, cramping pain

Refrigerate suppositories; protect from heat; freezing should be avoided

Ophthalmic: Keep bottle tightly closed; store at room temperature; discard 6 months after dropper is first placed in the solution

Osmotic dehydrating agent which increases osmotic pressure; draws fluid into colon and thus stimulates evacuation

Absorption:

Oral: Well absorbed

Rectal: Poorly absorbed

Decrease in intraocular pressure: Oral:

Onset of action: Within 10-30 minutes

Peak effect: Within 60-90 minutes

Duration: 4-8 hours

Reduction of intracranial pressure: Oral:

Onset of action: Within 10-60 minutes

Peak effect: Within 60-90 minutes

Duration: ~2-3 hours

Constipation: Suppository: Onset of action: 15-30 minutes

Serum half-life: 30-45 minutes

Constipation: Rectal:

Children <6 years: 1 infant suppository 1-2 times/day as needed or 2-5 mL as an enema

Children >6 years and Adults: 1 adult suppository 1-2 times/day as needed or 5-15 mL as an enema

Children and Adults:

Reduction of intraocular pressure: Oral: 1-1.8 g/kg 1-11/2 hours preoperatively; additional doses may be administered at 5-hour intervals

Reduction of intracranial pressure: Oral: 1.5 g/kg/day divided every 4 hours; 1 g/kg/dose every 6 hours has also been used

Reduction of corneal edema: Ophthalmic solution: Instill 1-2 drops in eye(s) prior to examination OR for lubricant effect, instill 1-2 drops in eye(s) every 3-4 hours

Oral: Orange or lemon juice may be added to unflavored 50% oral solution; pour solution over crushed ice and drink through a straw to improve palatability; headache can be minimized by having the patient lie down during and after administration

Rectal: Inset suppository high in the rectum and retain 15 minutes

No information available to require special precautions

No effects or complications reported

Do not use if experiencing abdominal pain, nausea, or vomiting

Use caution during insertion of suppository to avoid intestinal perforation, especially in neonates

Monitor blood glucose, intraocular pressure

Solution:

Ophthalmic, sterile (Ophthalgan®): Glycerin with chlorobutanol 0.55% (7.5 mL)

Oral (lime flavor)(Osmoglyn®): 50% (220 mL)

Rectal (Fleet® Babylax®): 4 mL/applicator (6s)

Suppository, rectal (Sani-Supp®): Glycerin with sodium stearate (infant and adult sizes)