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Pronunciation |
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(flure
an DREN oh
lide) |
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U.S. Brand
Names |
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Cordran®; Cordran®
SP |
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Generic
Available |
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No |
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Canadian Brand
Names |
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Drenison® |
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Synonyms |
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Flurandrenolone |
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Pharmacological Index |
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Corticosteroid, Topical |
|
|
Use |
|
Inflammation of corticosteroid-responsive dermatoses [medium potency topical
corticosteroid] |
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Pregnancy Risk
Factor |
|
C |
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Contraindications |
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Viral, fungal, or tubercular skin lesions, known hypersensitivity to
flurandrenolide |
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|
Warnings/Precautions |
|
Adverse systemic effects may occur when used on large areas of the body,
denuded areas, for prolonged periods of time, with an occlusive dressing, and/or
in infants or small children |
|
|
Adverse
Reactions |
|
<1%: Itching, dry skin, folliculitis, hypertrichosis, acneiform eruptions,
hypopigmentation, perioral dermatitis, allergic contact dermatitis, skin
atrophy, striae, miliaria, intracranial hypertension, acne, maceration of the
skin; HPA suppression, Cushing's syndrome, growth retardation, burning,
irritation, secondary infection |
|
|
Overdosage/Toxicology |
|
When consumed in excessive quantities, systemic hypercorticism and adrenal
suppression may occur; in those cases, discontinuation and withdrawal of the
corticosteroid should be done judiciously |
|
|
Drug
Interactions |
|
No data reported |
|
|
Mechanism of
Action |
|
Decreases inflammation by suppression of migration of polymorphonuclear
leukocytes and reversal of increased capillary permeability |
|
|
Pharmacodynamics/Kinetics |
|
Absorption: Adequate with intact skin
Metabolism: In the liver
Elimination: By the kidney with small amounts appearing in bile
Repeated applications lead to depot effects on skin, potentially resulting in
enhanced percutaneous absorption |
|
|
Usual Dosage |
|
Topical: Therapy should be discontinued when control is achieved; if no
improvement is seen, reassessment of diagnosis may be necessary.
Ointment, cream: Apply sparingly 1-2 times/day
Tape: Apply once daily
Adults: Cream, lotion, ointment: Apply sparingly 2-3 times/day
|
|
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Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
|
No information available to require special precautions |
|
|
Dental Health:
Effects on Dental Treatment |
|
No effects or complications reported |
|
|
Patient
Information |
|
A thin film of cream or ointment is effective; do not overuse; do not use
tight-fitting diapers or plastic pants on children being treated in the diaper
area; use only as prescribed, and for no longer than the period prescribed;
apply sparingly in light film; rub in lightly; avoid contact with eyes; notify
physician if condition being treated persists or worsens |
|
|
Nursing
Implications |
|
A thin film of cream or ointment is effective; do not overuse; do not use
tight-fitting diapers or plastic pants on children being treated in the diaper
area; use only as prescribed, and for no longer than the period prescribed;
apply sparingly in light film; rub in lightly; avoid contact with eyes; notify
physician if condition being treated persists or worsens |
|
|
Dosage Forms |
|
Cream, emulsified base (Cordran® SP): 0.025% (30 g, 60
g); 0.05% (15 g, 30 g, 60 g)
Lotion (Cordran®): 0.05% (15 mL, 60 mL)
Ointment, topical (Cordran®): 0.025% (30 g, 60 g);
0.05% (15 g, 30 g, 60 g)
Tape, topical (Cordran®): 4 mcg/cm2 (7.5 cm
x 60 cm, 7.5 cm x 200 cm rolls) |
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