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Flurandrenolide
Pronunciation
U.S. Brand Names
Generic Available
Canadian Brand Names
Synonyms
Pharmacological Index
Use
Pregnancy Risk Factor
Contraindications
Warnings/Precautions
Adverse Reactions
Overdosage/Toxicology
Drug Interactions
Mechanism of Action
Pharmacodynamics/Kinetics
Usual Dosage
Dental Health: Local Anesthetic/Vasoconstrictor Precautions
Dental Health: Effects on Dental Treatment
Patient Information
Nursing Implications
Dosage Forms

Pronunciation
(flure an DREN oh lide)

U.S. Brand Names
Cordran®; Cordran® SP

Generic Available

No


Canadian Brand Names
Drenison®

Synonyms
Flurandrenolone

Pharmacological Index

Corticosteroid, Topical


Use

Inflammation of corticosteroid-responsive dermatoses [medium potency topical corticosteroid]


Pregnancy Risk Factor

C


Contraindications

Viral, fungal, or tubercular skin lesions, known hypersensitivity to flurandrenolide


Warnings/Precautions

Adverse systemic effects may occur when used on large areas of the body, denuded areas, for prolonged periods of time, with an occlusive dressing, and/or in infants or small children


Adverse Reactions

<1%: Itching, dry skin, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, skin atrophy, striae, miliaria, intracranial hypertension, acne, maceration of the skin; HPA suppression, Cushing's syndrome, growth retardation, burning, irritation, secondary infection


Overdosage/Toxicology

When consumed in excessive quantities, systemic hypercorticism and adrenal suppression may occur; in those cases, discontinuation and withdrawal of the corticosteroid should be done judiciously


Drug Interactions

No data reported


Mechanism of Action

Decreases inflammation by suppression of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability


Pharmacodynamics/Kinetics

Absorption: Adequate with intact skin

Metabolism: In the liver

Elimination: By the kidney with small amounts appearing in bile

Repeated applications lead to depot effects on skin, potentially resulting in enhanced percutaneous absorption


Usual Dosage

Topical: Therapy should be discontinued when control is achieved; if no improvement is seen, reassessment of diagnosis may be necessary.

Ointment, cream: Apply sparingly 1-2 times/day

Tape: Apply once daily

Adults: Cream, lotion, ointment: Apply sparingly 2-3 times/day


Dental Health: Local Anesthetic/Vasoconstrictor Precautions

No information available to require special precautions


Dental Health: Effects on Dental Treatment

No effects or complications reported


Patient Information

A thin film of cream or ointment is effective; do not overuse; do not use tight-fitting diapers or plastic pants on children being treated in the diaper area; use only as prescribed, and for no longer than the period prescribed; apply sparingly in light film; rub in lightly; avoid contact with eyes; notify physician if condition being treated persists or worsens


Nursing Implications

A thin film of cream or ointment is effective; do not overuse; do not use tight-fitting diapers or plastic pants on children being treated in the diaper area; use only as prescribed, and for no longer than the period prescribed; apply sparingly in light film; rub in lightly; avoid contact with eyes; notify physician if condition being treated persists or worsens


Dosage Forms

Cream, emulsified base (Cordran® SP): 0.025% (30 g, 60 g); 0.05% (15 g, 30 g, 60 g)

Lotion (Cordran®): 0.05% (15 mL, 60 mL)

Ointment, topical (Cordran®): 0.025% (30 g, 60 g); 0.05% (15 g, 30 g, 60 g)

Tape, topical (Cordran®): 4 mcg/cm2 (7.5 cm x 60 cm, 7.5 cm x 200 cm rolls)


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