Yes

Androgen

Replacement of endogenous testicular hormone; in females, used as palliative treatment of breast cancer; stimulation of erythropoiesis, angioneurotic edema, postpartum breast engorgement

C-III

X

Serious cardiac disease, liver or kidney disease, hypersensitivity to fluoxymesterone or any component; pregnancy

May accelerate bone maturation without producing compensatory gain in linear growth in children; in prepubertal children perform radiographic examination of the hand and wrist every 6 months to determine the rate of bone maturation and to assess the effect of treatment on the epiphyseal centers

>10%:

Males: Priapism

Females: Menstrual problems (amenorrhea), virilism, breast soreness

Cardiovascular: Edema

Dermatologic: Acne

1% to 10%:

Males: Prostatic carcinoma, hirsutism (increase in pubic hair growth), impotence, testicular atrophy

Cardiovascular: Edema

Gastrointestinal: GI irritation, nausea, vomiting

Genitourinary: Prostatic hypertrophy

Hepatic: Hepatic dysfunction

<1%:

Males: Gynecomastia

Females: Amenorrhea

Hypercalcemia, leukopenia, polycythemia, hepatic necrosis, cholestatic hepatitis, hypersensitivity reactions

Symptoms of overdose include abnormal liver function tests, water retention

Decreased effect:

Fluphenazine effectiveness with anticholinergics

Barbiturate levels and decreased fluphenazine effectiveness when given together

Increased toxicity:

Anticoagulants: Fluoxymesterone may suppress clotting factors II, V, VII, and X; therefore, bleeding may occur in patients on anticoagulant therapy

Cyclosporine: May elevate cyclosporine serum levels

Insulin: May enhance hypoglycemic effect of insulin therapy

May decrease blood glucose concentrations and insulin requirements in patients with diabetes

With ethanol, effects of both drugs may increase

EPSEs and other CNS effects may increase when coadministered with lithium

May potentiate the effects of narcotics including respiratory depression

Protect from light

Synthetic androgenic anabolic hormone responsible for the normal growth and development of male sex hormones and development of male sex organs and maintenance of secondary sex characteristics; synthetic testosterone derivative with significant androgen activity; stimulates RNA polymerase activity resulting in an increase in protein production; increases bone development

Absorption: Oral: Rapid

Protein binding: 98%

Metabolism: In the liver

Half-life: 10-100 minutes

Elimination: Enterohepatic circulation and urinary excretion (90%)

Halogenated derivative of testosterone with up to 5 times the activity of methyltestosterone

Adults: Oral:

Hypogonadism: 5-20 mg/day

Delayed puberty: 2.5-20 mg/day for 4-6 months

Female:

Inoperable breast carcinoma: 10-40 mg/day in divided doses for 1-3 months

Breast engorgement: 2.5 mg after delivery, 5-10 mg/day in divided doses for 4-5 days

In prepubertal children, perform radiographic examination of the head and wrist every 6 months

Decreased levels of thyroxine-binding globulin; decreased total T₄ serum levels; increased resin uptake of T₃ and T₄

None reported

May cause leukopenia; use caution with clozapine and carbamazepine

No information available to require special precautions

No effects or complications reported

Take as directed; do not discontinue without consulting prescriber. Diabetics should monitor serum glucose closely and notify prescriber of changes; this medication can alter hypoglycemic requirements. You may experience acne, growth of body hair, loss of libido, impotence, or menstrual irregularity (usually reversible); nausea or vomiting (small frequent meals, frequent mouth care, sucking lozenges, or chewing gum may help). Report changes in menstrual pattern; deepening of voice or unusual growth of body hair; fluid retention (swelling of ankles, feet, or hands, difficulty breathing, or sudden weight gain); change in color of urine or stool; yellowing of eyes or skin; unusual bruising or bleeding; or other adverse reactions. Pregnancy/breast-feeding precautions: Inform prescriber if you are pregnant and do not get pregnant during or for 1 month following therapy. Consult prescriber for instruction on appropriate barrier contraceptive measures. This drug may cause severe fetal defects. Do not breast-feed.

In prepubertal children, perform radiographic examination of the head and wrist every 6 months

Tablet: 2 mg, 5 mg, 10 mg