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Pronunciation |
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(FLURE
e seen SOW dee
um) |
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U.S. Brand
Names |
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AK-Fluor Injection; Fluorescite® Injection;
Fluorets® Ophthalmic Strips; Fluor-I-Strip®;
Fluor-I-Strip-AT®; Flurate® Ophthalmic Solution;
Fluress® Ophthalmic Solution; Ful-Glo® Ophthalmic Strips;
Funduscein®
Injection |
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Generic
Available |
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Yes |
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Synonyms |
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Soluble Fluorescein |
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Pharmacological Index |
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Diagnostic Agent |
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Use |
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Demonstrates defects of corneal epithelium; diagnostic aid in ophthalmic
angiography |
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Pregnancy Risk
Factor |
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C (topical); X (parenteral) |
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Contraindications |
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Hypersensitivity to fluorescein or any other component of the product; do not
use with soft contact lenses, as this will cause them to discolor; pregnancy
with parenteral product |
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Warnings/Precautions |
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Use with caution in patients with history of hypersensitivity, allergies, or
asthma; avoid extravasation; should not be used in patients with soft contact
lenses, will cause them to discolor |
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Adverse
Reactions |
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1% to 10%:
Dermatologic: Burning sensation
Local: Temporary stinging
<1%: Syncope, hypotension, cardiac arrest, basilar artery ischemia, severe
shock, headache, nausea, GI distress, vomiting, thrombophlebitis
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Mechanism of
Action |
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Yellow, water soluble, dibasic acid xanthine dye which penetrates any break
in epithelial barrier to permit rapid penetration |
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Usual Dosage |
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Ophthalmic:
Solution: Instill 1-2 drops of 2% solution and allow a few seconds for
staining; wash out excess with sterile water or irrigating solution
Strips: Moisten strip with sterile water. Place moistened strip at the fornix
into the lower cul-de-sac close to the punctum. For best results, patient should
close lid tightly over strip until desired amount of staining is obtained.
Patient should blink several times after application.
Removal of foreign bodies, sutures or tonometry
(Fluress®): Instill 1 or 2 drops (single instillations)
into each eye before operating
Deep ophthalmic anesthesia (Fluress®): Instill 2 drops
into each eye every 90 seconds up to 3 doses
Injection: Prior to use, perform intradermal skin test; have epinephrine
1:1000, an antihistamine, and oxygen available
Children: 3.5 mg/lb (7.5 mg/kg) injected rapidly into antecubital vein
Adults: 500-750 mg injected rapidly into antecubital vein
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Patient
Information |
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Do not replace soft contact lenses for at least 1 hour, flush eye before
replacing; skin discoloration may last 6-12 hours, urine 24-36 hours if given
systemically |
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Nursing
Implications |
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Avoid extravasation, results in severe local tissue damage; have epinephrine
1:1000, an antihistamine, and oxygen available |
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Dosage Forms |
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Injection (AK-Fluor, Fluorescite®,
Funduscein®, Ophthifluor®): 10% [100
mg/mL] (5 mL); 25% [250 mg/mL] (2 mL, 3 mL)
Ophthalmic:
Solution: 2% [20 mg/mL] (1 mL, 2 mL, 15 mL)
Fluress®: 0.25% [2.5 mg/mL] with benoxinate 0.4% (5 mL)
Strip:
Ful-Glo®: 0.6 mg
Fluorets®, Fluor-I-Strip-AT®: 1
mg
Fluor-I-Strip®: 9 mg
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