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Fluorescein Sodium
Pronunciation
U.S. Brand Names
Generic Available
Synonyms
Pharmacological Index
Use
Pregnancy Risk Factor
Contraindications
Warnings/Precautions
Adverse Reactions
Mechanism of Action
Usual Dosage
Patient Information
Nursing Implications
Dosage Forms

Pronunciation
(FLURE e seen SOW dee um)

U.S. Brand Names
AK-Fluor Injection; Fluorescite® Injection; Fluorets® Ophthalmic Strips; Fluor-I-Strip®; Fluor-I-Strip-AT®; Flurate® Ophthalmic Solution; Fluress® Ophthalmic Solution; Ful-Glo® Ophthalmic Strips; Funduscein® Injection

Generic Available

Yes


Synonyms
Soluble Fluorescein

Pharmacological Index

Diagnostic Agent


Use

Demonstrates defects of corneal epithelium; diagnostic aid in ophthalmic angiography


Pregnancy Risk Factor

C (topical); X (parenteral)


Contraindications

Hypersensitivity to fluorescein or any other component of the product; do not use with soft contact lenses, as this will cause them to discolor; pregnancy with parenteral product


Warnings/Precautions

Use with caution in patients with history of hypersensitivity, allergies, or asthma; avoid extravasation; should not be used in patients with soft contact lenses, will cause them to discolor


Adverse Reactions

1% to 10%:

Dermatologic: Burning sensation

Local: Temporary stinging

<1%: Syncope, hypotension, cardiac arrest, basilar artery ischemia, severe shock, headache, nausea, GI distress, vomiting, thrombophlebitis


Mechanism of Action

Yellow, water soluble, dibasic acid xanthine dye which penetrates any break in epithelial barrier to permit rapid penetration


Usual Dosage

Ophthalmic:

Solution: Instill 1-2 drops of 2% solution and allow a few seconds for staining; wash out excess with sterile water or irrigating solution

Strips: Moisten strip with sterile water. Place moistened strip at the fornix into the lower cul-de-sac close to the punctum. For best results, patient should close lid tightly over strip until desired amount of staining is obtained. Patient should blink several times after application.

Removal of foreign bodies, sutures or tonometry (Fluress®): Instill 1 or 2 drops (single instillations) into each eye before operating

Deep ophthalmic anesthesia (Fluress®): Instill 2 drops into each eye every 90 seconds up to 3 doses

Injection: Prior to use, perform intradermal skin test; have epinephrine 1:1000, an antihistamine, and oxygen available

Children: 3.5 mg/lb (7.5 mg/kg) injected rapidly into antecubital vein

Adults: 500-750 mg injected rapidly into antecubital vein


Patient Information

Do not replace soft contact lenses for at least 1 hour, flush eye before replacing; skin discoloration may last 6-12 hours, urine 24-36 hours if given systemically


Nursing Implications

Avoid extravasation, results in severe local tissue damage; have epinephrine 1:1000, an antihistamine, and oxygen available


Dosage Forms

Injection (AK-Fluor, Fluorescite®, Funduscein®, Ophthifluor®): 10% [100 mg/mL] (5 mL); 25% [250 mg/mL] (2 mL, 3 mL)

Ophthalmic:

Solution: 2% [20 mg/mL] (1 mL, 2 mL, 15 mL)

Fluress®: 0.25% [2.5 mg/mL] with benoxinate 0.4% (5 mL)

Strip:

Ful-Glo®: 0.6 mg

Fluorets®, Fluor-I-Strip-AT®: 1 mg

Fluor-I-Strip®: 9 mg


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