>10% :
Central nervous system: Fatigue (22%), pain (13%), depression (13%), insomnia
(11%), anxiety (10%)
Endocrine & metabolic: Hot flashes (13%)
Gastrointestinal: Nausea (18%)
1% to 10%:
Central nervous system: Dizziness (8%), headache (8%), fever (5%),
hypoesthesia, confusion
Cardiovascular: Edema (7%), hypertension (5%), chest pain
Dermatologic: Rash, itching, alopecia
Gastrointestinal: Vomiting (7%), abdominal pain (6%), anorexia (6%),
constipation (5%), diarrhea (4%), increased appetite (3%), dyspepsia
Genitourinary: urinary tract infection
Neuromuscular & skeletal: Weakness, paresthesia, pathological fracture,
arthralgia
Miscellaneous: Influenza-like symptoms (6%), sweating (6%), lymphedema,
infection
Respiratory: Dyspnea (10%), cough (6%), bronchitis, sinusitis, pharyngitis,
rhinitis
<1%: Increase in transaminases and GGT
A dose-dependent decrease in sex-hormone binding globulin has been observed
with daily doses of 25 mg or more. Serum luteinizing hormone and
follicle-stimulating hormone levels have increased with this medicine.