|
Pronunciation |
|
(e
TOM i
date) |
|
|
U.S. Brand
Names |
|
Amidate®
Injection |
|
|
Generic
Available |
|
No |
|
|
Pharmacological Index |
|
General Anesthetic |
|
|
Use |
|
Induction of general anesthesia |
|
|
Pregnancy Risk
Factor |
|
C |
|
|
Contraindications |
|
Known hypersensitivity to etomidate |
|
|
Warnings/Precautions |
|
Consider exogenous corticosteroid replacement in patients undergoing severe
stress |
|
|
Adverse
Reactions |
|
>10%:
Gastrointestinal: Nausea, vomiting
Local: Pain at injection site
Neuromuscular & skeletal: Transient skeletal movements
Ocular: Uncontrolled eye movements
1% to 10%: Hiccups
<1%: Hypertension, hypotension, tachycardia, bradycardia, arrhythmias,
hyperventilation, hypoventilation, apnea, laryngospasm |
|
|
Overdosage/Toxicology |
|
Symptoms of overdose include respiratory arrest, coma
Supportive treatment |
|
|
Stability |
|
Store at room temperature |
|
|
Mechanism of
Action |
|
Ultrashort-acting nonbarbiturate hypnotic used for the induction of
anesthesia; chemically, it is a carboxylated imidazole and has been shown to
produce a rapid induction of anesthesia with minimal cardiovascular and
respiratory effects |
|
|
Pharmacodynamics/Kinetics |
|
Distribution: Vd: 3.6 to 4.5 L/kg; rapid into body tissues;
penetrates the central nervous system rapidly
Protein binding: 76%
Metabolism: Rapid in both liver and blood
Half-life: Terminal: 2.6 hours |
|
|
Usual Dosage |
|
Children >10 years and Adults: I.V.: 0.2-0.6 mg/kg over a period of 30-60
seconds for induction of anesthesia |
|
|
Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
|
No information available to require special precautions |
|
|
Dental Health:
Effects on Dental Treatment |
|
No effects or complications reported |
|
|
Nursing
Implications |
|
Store in refrigerator |
|
|
Dosage Forms |
|
Injection: 2 mg/mL (10 mL, 20
mL) |
|
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|