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Encainide
Pronunciation
U.S. Brand Names
Generic Available
Synonyms
Pharmacological Index
Use
Pregnancy Risk Factor
Contraindications
Adverse Reactions
Drug Interactions
Usual Dosage
Administration
Mental Health: Effects on Mental Status
Mental Health: Effects on Psychiatric Treatment
Dental Health: Local Anesthetic/Vasoconstrictor Precautions
Dental Health: Effects on Dental Treatment
Patient Information
Dosage Forms

Pronunciation
(en KAY nide)

U.S. Brand Names
Enkaid®

Generic Available

No


Synonyms
Encainide Hydrochloride

Pharmacological Index

Antiarrhythmic Agent, Class I-C


Use

Ventricular arrhythmias; supraventricular arrhythmias


Pregnancy Risk Factor

B


Contraindications

Hypersensitivity to encainide or any component; second or third degree A-V block; premature ventricular complexes; nonsustained ventricular arrhythmias; cardiogenic shock


Adverse Reactions

>10%:

Central nervous system: Dizziness

Ocular: Blurred vision

1% to 10%:

Cardiovascular: Chest pain congestive heart failure, ventricular tachycardia

Central nervous system: Headache

Gastrointestinal: Vomiting

Neuromuscular & skeletal: Weakness

Otic: Tinnitus


Drug Interactions

CYP2D6 enzyme substrate; beta-blockers (possible negative inotropic effects)


Usual Dosage

Adults: Oral: 25 mg every 8 hours; may increase to 35 mg every 8 hours after 3-5 days if needed; increase to 50 mg every 8 hours in another 3-5 days if response is not achieved


Administration

Give around-the-clock rather than 4 times/day, 3 times/day, etc (ie, 12-6-12-6, not 9-1-5-9) to promote less variation in peak and trough serum levels


Mental Health: Effects on Mental Status

Dizziness is common


Mental Health: Effects on Psychiatric Treatment

Use beta-blockers with caution; may produce additive negative inotropic effect; caution with TCAs


Dental Health: Local Anesthetic/Vasoconstrictor Precautions

No information available to require special precautions


Dental Health: Effects on Dental Treatment

No effects or complications reported


Patient Information

Take as directed; do not change dose except from advice of your physician; report any chest pain and irregular heartbeats


Dosage Forms

Capsule, as hydrochloride: 25 mg, 35 mg, 50 mg


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