|
Pronunciation |
|
(e
KONE a
zole) |
|
|
U.S. Brand
Names |
|
Spectazole™ |
|
|
Generic
Available |
|
No |
|
|
Canadian Brand
Names |
|
Ecostatin® |
|
|
Synonyms |
|
Econazole Nitrate |
|
|
Pharmacological Index |
|
Antifungal Agent, Topical |
|
|
Use |
|
Topical treatment of tinea pedis (athlete's foot), tinea cruris (jock itch),
tinea corporis (ringworm), tinea versicolor, and cutaneous
candidiasis |
|
|
Pregnancy Risk
Factor |
|
C |
|
|
Pregnancy/Breast-Feeding
Implications |
|
Clinical effect on the fetus: Do not use during the 1st trimester of
pregnancy, unless essential to a patient's welfare; use during the second and
third trimesters only if clearly needed |
|
|
Contraindications |
|
Known hypersensitivity to econazole or any component |
|
|
Warnings/Precautions |
|
Discontinue drug if sensitivity or chemical irritation occurs; not for
ophthalmic or intravaginal use |
|
|
Adverse
Reactions |
|
1% to 10%:
Local: Burning, stinging |
|
|
Drug
Interactions |
|
No data reported |
|
|
Mechanism of
Action |
|
Alters fungal cell wall membrane permeability; may interfere with RNA and
protein synthesis, and lipid metabolism |
|
|
Pharmacodynamics/Kinetics |
|
Absorption: Topical: <10%
Metabolism: In the liver to >20 metabolites
Elimination: <1% of applied dose recovered in urine or feces
|
|
|
Usual Dosage |
|
Children and Adults: Topical:
Cutaneous candidiasis: Apply sufficient quantity twice daily (morning and
evening)
Duration of treatment: Candidal infections and tinea cruris, versicolor, and
corporis should be treated for 2 weeks and tinea pedis for 1 month;
occasionally, longer treatment periods may be required |
|
|
Mental Health: Effects
on Mental Status |
|
None reported |
|
|
Mental Health:
Effects on Psychiatric
Treatment |
|
None reported |
|
|
Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
|
No information available to require special precautions |
|
|
Dental Health:
Effects on Dental Treatment |
|
No effects or complications reported |
|
|
Patient
Information |
|
For external use only. Apply exactly as directed and for the length of time
prescribed. Report if conditions worsens or persists or if infection occurs.
Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend
to be pregnant. Consult prescriber if breast-feeding. |
|
|
Nursing
Implications |
|
Candidal infections and tinea cruris, versicolor, and corporis should be
treated for 2 weeks and tinea pedis for 1 month; occasionally, longer treatment
periods may be required |
|
|
Dosage Forms |
|
Cream, as nitrate: 1% (15 g, 30 g, 85 g) |
|
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|