Yes

Theophylline Derivative

Bronchodilator in reversible airway obstruction due to asthma or COPD

C

Uncontrolled arrhythmias; hyperthyroidism

Uncommon at serum theophylline concentrations less than or equal to 20 mcg/mL

Cardiovascular: Tachycardia

Central nervous system: Nervousness, restlessness

Gastrointestinal: Nausea, vomiting

Dyphylline may decrease the effects of phenytoin, lithium, and neuromuscular blocking agents. Dyphylline may have synergistic toxicity with sympathomimetics. Cimetidine, ranitidine, allopurinol, beta-blockers (nonspecific), erythromycin, influenza virus vaccine, corticosteroids, ephedrine, quinolones, thyroid hormones, oral contraceptives, amiodarone, troleandomycin, clindamycin, carbamazepine, isoniazid, loop diuretics, and lincomycin may increase dyphylline concentrations. Cigarette and marijuana smoking, rifampin, barbiturates, hydantoins, ketoconazole, sulfinpyrazone, sympathomimetics, isoniazid, loop diuretics, carbamazepine, and aminoglutethimide may decrease dyphylline concentrations. Tetracyclines enhance toxicity and benzodiazepine's action may be antagonized.

Children: I.M.: 4.4-6.6 mg/kg/day in divided doses

Adults:

Oral: Up to 15 mg/kg 4 times/day, individualize dosage

I.M.: 250-500 mg, do not exceed total dosage of 15 mg/kg every 6 hours

Dosing adjustment in renal impairment:

Cl_cr 50-80 mL/minute: Administer 75% of normal dose

Cl_cr 10-50 mL/minute: Administer 50% of normal dose

Cl_cr <10 mL/minute: Administer 25% of normal dose

Should be administered with water 1 hour before or 1 hour after meals

Not for I.V. administration, inject slowly

May cause nervousness, restlessness, or insomnia

May decrease serum lithium levels; monitor; barbiturates and carbamazepine may decrease dyphylline levels; may antagonize effects of benzodiazepines

No information available to require special precautions

Do not prescribe any erythromycin product to patients taking theophylline products. Erythromycin will delay the normal metabolic inactivation of theophyllines leading to increased blood levels; this has resulted in nausea, vomiting and CNS restlessness

Take at regular intervals with a full glass of water; do not ingest large amounts of caffeine-containing beverages or foods; do not take more than the recommended dose

Not for I.V. administration, inject slowly; administer oral form around-the-clock rather than 4 times/day, 3 times/day, etc, (ie, 12-6-12-6, not 9-1-5-9) to promote less variation in peak and trough serum levels; monitor vital signs, serum concentrations, and CNS effects (insomnia, irritability); encourage patient to drink adequate fluids (2 L/day) to decrease mucous viscosity in airways

Elixir:

Lufyllin®: 100 mg/15 mL with alcohol 20% (473 mL, 3780 mL)

Dilor®: 160 mg/15 mL with alcohol 18% (473 mL)

Injection (Dilor®, Lufyllin®): 250 mg/mL (2 mL)

Tablet: 200 mg, 400 mg

Dilor®, Lufyllin®: 200 mg, 400 mg