No

Local Anesthetic; Local Anesthetic, Oral

Local anesthetic prior to laryngoscopy, bronchoscopy, or endotracheal intubation; use topically for temporary relief of pain associated with oral mucosa or anogenital lesions

C

Contraindicated in patients allergic to chlorobutanol (preservative used in dyclonine) or dyclonine

Use with caution in patients with sepsis or traumatized mucosa in the area of application to avoid rapid systemic absorption; may impair swallowing and enhance the danger of aspiration; use with caution in patients with shock or heart block; resuscitative equipment, oxygen, and resuscitative drugs should be immediately available when dyclonine topical solution is administered to mucous membranes; not for injection or ophthalmic use

<1%: Hypotension, bradycardia, respiratory arrest, cardiac arrest, excitation, drowsiness, nervousness, dizziness, seizures, slight irritation and stinging may occur when applied, blurred vision, allergic reactions

Symptoms of overdose are primarily CNS (seizures, excitation) and cardiovascular (hypotension, myocardial depression)

Treatment is supportive with fluids and pressors (particularly those that stimulate the myocardium); diazepam 0.1 mg/kg can be used to control seizures

No data reported

Store in tight, light-resistant containers

Blocks impulses at peripheral nerve endings in skin and mucous membranes by altering cell membrane permeability to ionic transfer

Onset of local anesthesia: 2-10 minutes

Duration: 30-60 minutes

Use the lowest dose needed to provide effective anesthesia

Mouth sores: 5-10 mL of 0.5% or 1% to oral mucosa (swab or swish and then spit) 3-4 times/day as needed; maximum single dose: 200 mg (40 mL of 0.5% solution or 20 mL of 1% solution)

Bronchoscopy: Use 2 mL of the 1% solution or 4 mL of the 0.5% solution sprayed onto the larynx and trachea every 5 minutes until the reflex has been abolished

Food should not be ingested for 60 minutes following application in the mouth or throat area

No information available to require special precautions

No effects or complications reported

This medication is given to reduce sensation in the injected area. When used in mouth or throat; do not eat or drink anything for at least 1 hour following treatment. Take small sips of water at first to ensure that you can swallow without difficulty. Your tongue and mouth may be numb - use caution to avoid biting yourself. Immediately report swelling of face, lips, tongue; chest pain or palpitations; increased restlessness, confusion, anxiety, or dizziness. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to be pregnant. Consult prescriber if breast-feeding.

Use the lowest dose needed to provide effective anesthesia; not for injection; do not apply nasally or to the eye

Lozenges, as hydrochloride: 1.2 mg, 3 mg

Solution, topical, as hydrochloride: 0.5% (30 mL); 1% (30 mL)

Carnel SB, Blakeslee DB, Oswald SG, et al, "Treatment of Radiation- and Chemotherapy-Induced Stomatitis," Otolaryngol Head Neck Surg, 1990, 102(4):326-30.

Gargiulo AV, Burns GM, and Huck CP, "Dyclonine Hydrochloride - A Topical Agent for Managing Pain," Ill Dent J, 1992, 61(4):303-4.

Nelson LA, "Nonprescription Drug Screening. Dyclonine Hydrochloride," Am Pharm, 1987, NS27(9):27-9.