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Pronunciation |
|
(droe
PER i dole & FEN ta
nil) |
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U.S. Brand
Names |
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Innovar® |
|
|
Generic
Available |
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Yes |
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Synonyms |
|
Fentanyl and Droperidol |
|
|
Pharmacological Index |
|
Analgesic, Narcotic |
|
|
Use |
|
Produce and maintain analgesia and sedation during diagnostic or surgical
procedures (neuroleptanalgesia and neuroleptanesthesia); adjunct to general
anesthesia |
|
|
Pregnancy Risk
Factor |
|
C |
|
|
Contraindications |
|
Hypersensitivity to droperidol or fentanyl; patients who have taken MAO
inhibitors within 14 days |
|
|
Adverse
Reactions |
|
>10%:
Cardiovascular: Bradycardia, mild to moderate hypotension, tachycardia
Central nervous system: Drowsiness, nausea, vomiting, postoperative
drowsiness
Respiratory: Respiratory depression
1% to 10%:
Cardiovascular: Cardiac arrhythmia, orthostatic hypotension, hypertension
Central nervous system: Confusion, CNS depression, extrapyramidal reactions
Gastrointestinal: Biliary spasm
Ocular: Blurred vision
Respiratory: Respiratory depression |
|
|
Drug
Interactions |
|
CNS depressant drugs may cause additive effects; may cause hypertensive
crisis if given with MAO inhibitors |
|
|
Usual Dosage |
|
Children:
Premedication: I.M.: 0.03 mL/kg 30-60 minutes prior to surgery
Adjunct to general anesthesia: I.V.: Total dose: 0.05 mL/kg as slow infusion
(1 mL/1-2 minutes) until sleep occurs
Adults:
Premedication: I.M.: 0.5-2 mL 30-60 minutes prior to surgery
Adjunct to general anesthesia: I.V.: 0.09-0.11 mL/kg as slow infusion (1
mL/1-2 minutes) until sleep occurs |
|
|
Mental Health: Effects
on Mental Status |
|
Drowsiness is common; may cause depression or extrapyramidal symptoms; rarely
may produce delirium or hallucinations |
|
|
Mental Health:
Effects on Psychiatric
Treatment |
|
Contraindicated within 14 days of MAOIs; concurrent use with psychotropics
may produce additive sedation |
|
|
Patient
Information |
|
See individual agents. Pregnancy/breast-feeding precautions: Inform
prescriber if you are or intend to get pregnant. Consult prescriber if
breast-feeding. |
|
|
Nursing
Implications |
|
An opioid antagonist, resuscitative and intubation equipment, and oxygen
should be available
Monitor O2 saturation, blood pressure, vital signs
|
|
|
Dosage Forms |
|
Injection: Droperidol 2.5 mg and fentanyl 50 mcg per mL (2 mL, 5
mL) |
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