Diphenhydramine and Pseudoephedrine

Look Up > Drugs > Diphenhydramine and Pseudoephedrine

	Pronunciation
	U.S. Brand Names
	Generic Available
	Pharmacological Index
	Use
	Adverse Reactions

	Drug Interactions
	Usual Dosage
	Dental Health: Local Anesthetic/Vasoconstrictor Precautions
	Dental Health: Effects on Dental Treatment
	Dosage Forms

Pronunciation

(dye fen HYE dra meen & soo doe e FED rin)

U.S. Brand Names

Actifed® Allergy Tablet (Night) [OTC]; Banophen® Decongestant Capsule [OTC]; Benadryl® Decongestant Allergy Tablet [OTC]

Generic Available

Yes

Pharmacological Index

Antihistamine/Decongestant Combination

Use

Relief of symptoms of upper respiratory mucosal congestion in seasonal and perennial nasal allergies, acute rhinitis, rhinosinusitis, and eustachian tube blockage

Adverse Reactions

See individual agents

Drug Interactions

See individual agents

Usual Dosage

Adults: Oral: 1 capsule or tablet every 4-6 hours, up to 4/day

Dental Health: Local Anesthetic/Vasoconstrictor Precautions

Use with caution since pseudoephedrine is a sympathomimetic amine which could interact with epinephrine to cause a pressor response

Dental Health: Effects on Dental Treatment

Chronic use of antihistamines will inhibit salivary flow, particularly in elderly patients; this may contribute to periodontal disease and oral discomfort

Dosage Forms

Capsule: Diphenhydramine hydrochloride 25 mg and pseudoephedrine hydrochloride 60 mg

Tablet:

Actifed® Allergy (Night): Diphenhydramine hydrochloride 25 mg and pseudoephedrine hydrochloride 30 mg

Benadryl® Decongestant Allergy: Diphenhydramine hydrochloride 25 mg and pseudoephedrine hydrochloride 60 mg