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Diflorasone
Pronunciation
U.S. Brand Names
Generic Available
Synonyms
Pharmacological Index
Use
Pregnancy Risk Factor
Contraindications
Warnings/Precautions
Adverse Reactions
Overdosage/Toxicology
Drug Interactions
Mechanism of Action
Pharmacodynamics/Kinetics
Usual Dosage
Dental Health: Local Anesthetic/Vasoconstrictor Precautions
Dental Health: Effects on Dental Treatment
Patient Information
Nursing Implications
Dosage Forms

Pronunciation
(dye FLOR a sone)

U.S. Brand Names
Florone®; Florone E®; Maxiflor®; Psorcon™

Generic Available

No


Synonyms
Diflorasone Diacetate

Pharmacological Index

Corticosteroid, Topical


Use

Relieves inflammation and pruritic symptoms of corticosteroid-responsive dermatosis (high to very high potency topical corticosteroid)

Psorcon™: Very high potency topical corticosteroid


Pregnancy Risk Factor

C


Contraindications

Known hypersensitivity to diflorasone


Warnings/Precautions

Use with caution in patients with impaired circulation; skin infections


Adverse Reactions

<1%: Itching, folliculitis, maceration, burning, dryness, muscle atrophy, arthralgia, secondary infection


Overdosage/Toxicology

Symptoms of overdose include moon face, central obesity, hypertension, diabetes, hyperlipidemia, peptic ulcer, increased susceptibility to infection, electrolyte and fluid imbalance, psychosis, hallucinations. When consumed in excessive quantities, systemic hypercorticism and adrenal suppression may occur; in those cases discontinuation and withdrawal of the corticosteroid should be done judiciously.


Drug Interactions

No data reported


Mechanism of Action

Decreases inflammation by suppression of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability


Pharmacodynamics/Kinetics

Absorption: Topical: Negligible, around 1% reaches dermal layers or systemic circulation; occlusive dressings increase absorption percutaneously

Metabolism: Primarily in the liver


Usual Dosage

Topical: Apply ointment sparingly 1-3 times/day; apply cream sparingly 2-4 times/day. Therapy should be discontinued when control is achieved; if no improvement is seen, reassessment of diagnosis may be necessary.


Dental Health: Local Anesthetic/Vasoconstrictor Precautions

No information available to require special precautions


Dental Health: Effects on Dental Treatment

No effects or complications reported


Patient Information

A thin film of cream or ointment is effective; do not overuse; do not use tight-fitting diapers or plastic pants on children being treated in the diaper area; use only as prescribed, and for no longer than the period prescribed; apply sparingly in light film; rub in lightly; avoid contact with eyes; notify physician if condition being treated persists or worsens


Nursing Implications

For external use only; do not use on open wounds; apply sparingly to occlusive dressings; should not be used in the presence of open or weeping lesions


Dosage Forms

Cream, as diacetate: 0.05% (15 g, 30 g, 60 g)

Ointment, topical, as diacetate: 0.05% (15 g, 30 g, 60 g)


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