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Pronunciation |
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(dye
FLOR a
sone) |
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U.S. Brand
Names |
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Florone®; Florone E®;
Maxiflor®; Psorcon™ |
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Generic
Available |
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No |
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Synonyms |
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Diflorasone Diacetate |
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Pharmacological Index |
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Corticosteroid, Topical |
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Use |
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Relieves inflammation and pruritic symptoms of corticosteroid-responsive
dermatosis (high to very high potency topical corticosteroid)
Psorcon™: Very high potency topical corticosteroid
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Pregnancy Risk
Factor |
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C |
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Contraindications |
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Known hypersensitivity to diflorasone |
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Warnings/Precautions |
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Use with caution in patients with impaired circulation; skin
infections |
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Adverse
Reactions |
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<1%: Itching, folliculitis, maceration, burning, dryness, muscle atrophy,
arthralgia, secondary infection |
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Overdosage/Toxicology |
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Symptoms of overdose include moon face, central obesity, hypertension,
diabetes, hyperlipidemia, peptic ulcer, increased susceptibility to infection,
electrolyte and fluid imbalance, psychosis, hallucinations. When consumed in
excessive quantities, systemic hypercorticism and adrenal suppression may occur;
in those cases discontinuation and withdrawal of the corticosteroid should be
done judiciously. |
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Drug
Interactions |
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No data reported |
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Mechanism of
Action |
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Decreases inflammation by suppression of migration of polymorphonuclear
leukocytes and reversal of increased capillary permeability |
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Pharmacodynamics/Kinetics |
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Absorption: Topical: Negligible, around 1% reaches dermal layers or systemic
circulation; occlusive dressings increase absorption percutaneously
Metabolism: Primarily in the liver |
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Usual Dosage |
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Topical: Apply ointment sparingly 1-3 times/day; apply cream sparingly 2-4
times/day. Therapy should be discontinued when control is achieved; if no
improvement is seen, reassessment of diagnosis may be
necessary. |
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Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
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No information available to require special precautions |
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Dental Health:
Effects on Dental Treatment |
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No effects or complications reported |
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Patient
Information |
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A thin film of cream or ointment is effective; do not overuse; do not use
tight-fitting diapers or plastic pants on children being treated in the diaper
area; use only as prescribed, and for no longer than the period prescribed;
apply sparingly in light film; rub in lightly; avoid contact with eyes; notify
physician if condition being treated persists or worsens |
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Nursing
Implications |
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For external use only; do not use on open wounds; apply sparingly to
occlusive dressings; should not be used in the presence of open or weeping
lesions |
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Dosage Forms |
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Cream, as diacetate: 0.05% (15 g, 30 g, 60 g)
Ointment, topical, as diacetate: 0.05% (15 g, 30 g, 60 g)
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