|
Pronunciation |
|
(dye
klor FEN a
mide) |
|
|
U.S. Brand
Names |
|
Daranide® |
|
|
Generic
Available |
|
No |
|
|
Synonyms |
|
Diclofenamide |
|
|
Pharmacological Index |
|
Carbonic Anhydrase Inhibitor; Diuretic, Carbonic Anhydrase Inhibitor; Ophthalmic
Agent, Antiglaucoma |
|
|
Use |
|
Adjunct in treatment of open-angle glaucoma and perioperative treatment for
angle-closure glaucoma |
|
|
Pregnancy Risk
Factor |
|
C |
|
|
Contraindications |
|
Severe pulmonary obstruction; severe renal impairment; hypersensitivity to
dichlorphenamide |
|
|
Adverse
Reactions |
|
>10%:
Central nervous system: Fatigue, malaise
Gastrointestinal: Diarrhea, anorexia, metallic taste
Genitourinary: Polyuria
1% to 10%:
Central nervous system: Mental depression, drowsiness
Renal: Renal calculi |
|
|
Drug
Interactions |
|
Increased lithium excretion and altered excretion of other drugs by
alkalinization of the urine |
|
|
Usual Dosage |
|
Adults: Oral: 100-200 mg to start followed by 100 mg every 12 hours until
desired response is obtained; maintenance dose: 25-50 mg 1-3
times/day |
|
|
Mental Health: Effects
on Mental Status |
|
Sedation is common; may cause depression |
|
|
Mental Health:
Effects on Psychiatric
Treatment |
|
May rarely cause bone marrow suppression; use caution with clozapine and
carbamazepine; may increase the excretion of lithium but should not be used to
treat lithium toxicity |
|
|
Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
|
No information available to require special precautions |
|
|
Dental Health:
Effects on Dental Treatment |
|
No effects or complications reported |
|
|
Patient
Information |
|
Report numbness or tingling of extremities to physician; ability to perform
tasks requiring mental alertness and/or physical coordination may be impaired;
take with food if GI upset occurs; notify if flank pain or rash
occurs |
|
|
Nursing
Implications |
|
Monitor electrolytes |
|
|
Dosage Forms |
|
Tablet: 50 mg |
|
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|