No

Plasma Volume Expander

Prophylaxis of serious anaphylactic reactions to I.V. infusion of dextran

C

Hypersensitivity to dextrans or any component; dextran contraindicated

Severe hypotension and bradycardia can occur. If any reaction occurs, do not administer dextran. Mild dextran-induced anaphylactic reactions are not prevented.

<1% (Limited to important or life-threatening symptoms): Mild hypotension, tightness of chest, wheezing

Protect from freezing

Binds to dextran-reactive immunoglobulin without bridge formation and no formation of large immune complexes

I.V. (time between dextran 1 and dextran solution should not exceed 15 minutes):

Adults: 20 mL 1-2 minutes before I.V. infusion of dextran

Dextran use in patients with restrictive cardiovascular disease or renal and hepatic impairment should be used with extreme caution. Dextran can also result in an anaphylactoid reaction. Patients should be observed closely during the first several minutes of the infusion in case anaphylactoid reaction occurs.

No information available to require special precautions

No effects or complications reported

Do not dilute or admix with dextrans

Injection: 150 mg/mL (20 mL)

Renck H, Ljungstrom KG, Hedin H, et al, "Prevention of Dextran-Induced Anaphylactic Reactions by Hapten Inhibition," Acta Chir Scand, 1983, 149(4):355-60.