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Pronunciation |
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(deks
PAN the
nole) |
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|
U.S. Brand
Names |
|
Ilopan-Choline® Oral; Ilopan®
Injection; Panthoderm® Cream
[OTC] |
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|
Generic
Available |
|
Yes |
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|
Synonyms |
|
Pantothenyl Alcohol |
|
|
Pharmacological Index |
|
Gastrointestinal Agent, Stimulant |
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|
Use |
|
Prophylactic use to minimize paralytic ileus, treatment of postoperative
distention |
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Pregnancy Risk
Factor |
|
C |
|
|
Contraindications |
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Hemophilia; mechanical obstruction of ileus |
|
|
Adverse
Reactions |
|
<1%:
Dermatologic: Dermatitis, urticaria
Gastrointestinal: Vomiting, diarrhea, hyperperistalsis
Hematologic: Prolonged bleeding time
Local: Irritation
Neuromuscular & skeletal: Paresthesia
Respiratory: Dyspnea |
|
|
Drug
Interactions |
|
Increased/prolonged effect of succinylcholine (do not administer within 1
hour) |
|
|
Mechanism of
Action |
|
A pantothenic acid B vitamin analog that is converted to coenzyme A
internally; coenzyme A is essential to normal fatty acid synthesis, amino acid
synthesis and acetylation of choline in the production of the neurotransmitter,
acetylcholine |
|
|
Pharmacodynamics/Kinetics |
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Absorption: Well absorbed |
|
|
Usual Dosage |
|
Children and Adults: Relief of itching and aid in skin healing: Topical:
Apply to affected area 1-2 times/day
Adults:
Relief of gas retention: Oral: 2-3 tablets 3 times/day
Prevention of postoperative ileus: I.M.: 250-500 mg stat, repeat in 2 hours,
followed by doses every 6 hours until danger passes
Paralyzed ileus: I.M.: 500 mg stat, repeat in 2 hours, followed by doses
every 6 hours, if needed |
|
|
Administration |
|
Not for direct I.V. administration; must be diluted |
|
|
Mental Health: Effects
on Mental Status |
|
None reported |
|
|
Mental Health:
Effects on Psychiatric
Treatment |
|
None reported |
|
|
Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
|
No information available to require special precautions |
|
|
Dental Health:
Effects on Dental Treatment |
|
No effects or complications reported |
|
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Nursing
Implications |
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Not for direct I.V. administration |
|
|
Dosage Forms |
|
Cream: 2% (30 g, 60 g)
Injection (Ilopan®): 250 mg/mL (2 mL, 10 mL, 30 mL)
Tablet (Ilopan-Choline®): 50 mg with choline bitartrate
25 mg |
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