Yes

Antihistamine

Perennial and seasonal allergic rhinitis and other allergic symptoms including urticaria

B

Narrow-angle glaucoma, hypersensitivity to dexchlorpheniramine or any component

Bladder neck obstruction, symptomatic prostatic hypertrophy, asthmatic attack, and stenosing peptic ulcer

>10%:

Central nervous system: Slight to moderate drowsiness

Respiratory: Thickening of bronchial secretions

1% to 10%:

Central nervous system: Headache, fatigue, nervousness, dizziness

Gastrointestinal: Appetite increase, weight increase, nausea, diarrhea, abdominal pain, xerostomia

Neuromuscular & skeletal: Arthralgia

Respiratory: Pharyngitis

Symptoms of overdose include dry mouth, flushed skin, dilated pupils, CNS depression. There is no specific treatment for antihistamine overdose. Clinical toxicity is due to blockade of cholinergic receptors. For anticholinergic overdose with severe life-threatening symptoms, physostigmine 1-2 mg I.V. slowly, may be given to reverse these effects.

Increased effect/toxicity: CNS depressants, MAO inhibitors, TCAs, phenothiazines, guanabenz

Competes with histamine for H₁-receptor sites on effector cells in the gastrointestinal tract, blood vessels, and respiratory tract

Onset of action: ~1 hour

Duration: 3-6 hours

Absorption: Well absorbed from GI tract

Oral:

2-5 years: 0.5 mg every 4-6 hours (do not use timed release)

6-11 years: 1 mg every 4-6 hours or 4 mg timed release at bedtime

Adults: 2 mg every 4-6 hours or 4-6 mg timed release at bedtime or every 8-10 hours

May be administered with food or water

Drowsiness is common; may cause nervousness and depression

Concurrent use with psychotropics may cause additive sedation

No information available to require special precautions

Up to 10% of patients will complain of significant dry mouth and drowsiness. This will disappear with cessation of drug therapy.

Take as directed; do not exceed recommended dose. Do not chew or crush sustained release tablet. Avoid use of other depressants, alcohol, or sleep-inducing medications unless approved by prescriber. You may experience drowsiness or dizziness (use caution when driving or engaging in tasks requiring alertness until response to drug is known); or dry mouth, nausea, or abdominal pain (frequent small meals, frequent mouth care, chewing gum, or sucking hard candy may help). Report persistent sedation, confusion, or agitation; changes in urinary pattern; blurred vision; sore throat, difficulty breathing or expectorating (thick secretions); or lack of improvement or worsening or condition. Breast-feeding precautions: Breast-feeding is not recommended.

May cause drowsiness; swallow whole, do not crush or chew sustained release product; avoid alcohol, may impair coordination and judgment

Syrup, as maleate (orange flavor): 2 mg/5 mL with alcohol 6% (480 mL)

Tablet, as maleate: 2 mg

Tablet, as maleate, sustained action: 4 mg, 6 mg