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Pronunciation |
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(des
oks i MET a
sone) |
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U.S. Brand
Names |
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Topicort®;
Topicort®-LP |
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Generic
Available |
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Yes |
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Pharmacological Index |
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Corticosteroid, Topical |
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Use |
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Relieves inflammation and pruritic symptoms of corticosteroid-responsive
dermatosis [medium to high potency topical corticosteroid] |
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Pregnancy Risk
Factor |
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C |
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Contraindications |
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Known hypersensitivity to desoximetasone, topical fungal infections,
tuberculosis of skin herpes simplex |
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|
Warnings/Precautions |
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Use with caution in patients with impaired circulation; skin
infections |
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Adverse
Reactions |
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<1%: Itching, dry skin, folliculitis, hypertrichosis, acneiform eruptions,
allergic contact dermatitis, skin maceration, skin atrophy, striae, perioral
dermatitis, hypopigmentation; local burning, irritation, miliaria; secondary
infection |
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Overdosage/Toxicology |
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Symptoms of overdose include moon face, central obesity, hypertension,
diabetes, hyperlipidemia, peptic ulcer, increased susceptibility to infection,
electrolyte and fluid imbalance, psychosis, hallucinations. When consumed in
excessive quantities, systemic hypercorticism and adrenal suppression may occur;
in those cases discontinuation and withdrawal of the corticosteroid should be
done judiciously. |
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Drug
Interactions |
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No data reported |
|
|
Mechanism of
Action |
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Stimulates the synthesis of enzymes needed to decrease inflammation, suppress
mitotic activity, and cause vasoconstriction; high potency, fluorinated topical
corticosteroid |
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Pharmacodynamics/Kinetics |
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Topical:
Distribution: Only small amounts reach the systemic circulation or dermal
layers |
|
|
Usual Dosage |
|
Desoximetasone is a potent fluorinated topical corticosteroid. All of the
preparations are considered high potency. Therapy should be discontinued when
control is achieved; if no improvement is seen, reassessment of diagnosis may be
necessary.
Adults: Apply sparingly in a thin film twice daily |
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Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
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No information available to require special precautions |
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Dental Health:
Effects on Dental Treatment |
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No effects or complications reported |
|
|
Patient
Information |
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A thin film of cream or ointment is effective, do not overuse; rub in
lightly; do not use tight-fitting diapers or plastic pants on children being
treated in the diaper area; use only as prescribed and for no longer than the
period prescribed; avoid contact with eyes; notify physician if condition being
treated persists or worsens |
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Nursing
Implications |
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For external use only; apply sparingly to occlusive dressings; should not be
used in the presence of open or weeping lesions |
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Dosage Forms |
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Topical:
Topicort®: 0.25% (15 g, 60 g, 120 g)
Topicort®-LP: 0.05% (15 g, 60 g)
Gel, topical: 0.05% (15 g, 60 g)
Ointment (Topicort®): 0.25% (15 g, 60 g)
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