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Desoximetasone
Pronunciation
U.S. Brand Names
Generic Available
Pharmacological Index
Use
Pregnancy Risk Factor
Contraindications
Warnings/Precautions
Adverse Reactions
Overdosage/Toxicology
Drug Interactions
Mechanism of Action
Pharmacodynamics/Kinetics
Usual Dosage
Dental Health: Local Anesthetic/Vasoconstrictor Precautions
Dental Health: Effects on Dental Treatment
Patient Information
Nursing Implications
Dosage Forms

Pronunciation
(des oks i MET a sone)

U.S. Brand Names
Topicort®; Topicort®-LP

Generic Available

Yes


Pharmacological Index

Corticosteroid, Topical


Use

Relieves inflammation and pruritic symptoms of corticosteroid-responsive dermatosis [medium to high potency topical corticosteroid]


Pregnancy Risk Factor

C


Contraindications

Known hypersensitivity to desoximetasone, topical fungal infections, tuberculosis of skin herpes simplex


Warnings/Precautions

Use with caution in patients with impaired circulation; skin infections


Adverse Reactions

<1%: Itching, dry skin, folliculitis, hypertrichosis, acneiform eruptions, allergic contact dermatitis, skin maceration, skin atrophy, striae, perioral dermatitis, hypopigmentation; local burning, irritation, miliaria; secondary infection


Overdosage/Toxicology

Symptoms of overdose include moon face, central obesity, hypertension, diabetes, hyperlipidemia, peptic ulcer, increased susceptibility to infection, electrolyte and fluid imbalance, psychosis, hallucinations. When consumed in excessive quantities, systemic hypercorticism and adrenal suppression may occur; in those cases discontinuation and withdrawal of the corticosteroid should be done judiciously.


Drug Interactions

No data reported


Mechanism of Action

Stimulates the synthesis of enzymes needed to decrease inflammation, suppress mitotic activity, and cause vasoconstriction; high potency, fluorinated topical corticosteroid


Pharmacodynamics/Kinetics

Topical:

Distribution: Only small amounts reach the systemic circulation or dermal layers


Usual Dosage

Desoximetasone is a potent fluorinated topical corticosteroid. All of the preparations are considered high potency. Therapy should be discontinued when control is achieved; if no improvement is seen, reassessment of diagnosis may be necessary.

Adults: Apply sparingly in a thin film twice daily


Dental Health: Local Anesthetic/Vasoconstrictor Precautions

No information available to require special precautions


Dental Health: Effects on Dental Treatment

No effects or complications reported


Patient Information

A thin film of cream or ointment is effective, do not overuse; rub in lightly; do not use tight-fitting diapers or plastic pants on children being treated in the diaper area; use only as prescribed and for no longer than the period prescribed; avoid contact with eyes; notify physician if condition being treated persists or worsens


Nursing Implications

For external use only; apply sparingly to occlusive dressings; should not be used in the presence of open or weeping lesions


Dosage Forms

Topical:

Topicort®: 0.25% (15 g, 60 g, 120 g)

Topicort®-LP: 0.05% (15 g, 60 g)

Gel, topical: 0.05% (15 g, 60 g)

Ointment (Topicort®): 0.25% (15 g, 60 g)


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