No

Antihistamine

Prevention and treatment of nausea, vomiting, and vertigo associated with motion sickness; control of postoperative nausea and vomiting

B

Hypersensitivity to cyclizine or any component

>10%:

Central nervous system: Drowsiness

Gastrointestinal: Xerostomia

1% to 10%:

Central nervous system: Headache

Dermatologic: Dermatitis

Gastrointestinal: Nausea

Genitourinary: Urinary retention

Ocular: Diplopia

Renal: Polyuria

Increased effect/toxicity with CNS depressants, alcohol

I.M. formulation is incompatible when mixed in the same syringe with tetracyclines, methohexital, penicillin, pentobarbital, phenobarbital, secobarbital, thiopental

Cyclizine is a piperazine derivative with properties of histamines. The precise mechanism of action in inhibiting the symptoms of motion sickness is not known. It may have effects directly on the labyrinthine apparatus and central actions on the labyrinthine apparatus and on the chemoreceptor trigger zone. Cyclizine exerts a central anticholinergic action.

Oral:

Adults: 50 mg taken 30 minutes before departure, may repeat in 4-6 hours if needed, up to 200 mg/day

Drowsiness is common

Concurrent use with psychotropics may exacerbate the dry mouth and sedation commonly seen with cyclizine

No information available to require special precautions

>10% of patients will experience dry mouth

May cause drowsiness, may impair judgment and coordination; avoid alcohol; drink plenty of fluids for dry mouth and to prevent constipation

Monitor CNS effects or unusual movements

Injection, as lactate: 50 mg/mL (1 mL)

Tablet, as hydrochloride: 50 mg