No

Enzyme, Topical Debridement

Promotes debridement of necrotic tissue in dermal ulcers and severe burns

C

Known hypersensitivity to collagenase

For external use only; avoid contact with eyes; monitor debilitated patients for systemic bacterial infections because debriding enzymes may increase the risk of bacteremia

1% to 10%: Local: Irritation

<1%: Pain and burning may occur at site of application

Action of enzyme may be stopped by applying Burow's solution

Decreased effect: Enzymatic activity is inhibited by detergents, benzalkonium chloride, hexachlorophene, nitrofurazone, tincture of iodine, and heavy metal ions (silver and mercury)

Collagenase is an enzyme derived from the fermentation of Clostridium histolyticum and differs from other proteolytic enzymes in that its enzymatic action has a high specificity for native and denatured collagen. Collagenase will not attack collagen in healthy tissue or newly formed granulation tissue. In addition, it does not act on fat, fibrin, keratin, or muscle.

Topical: Apply once daily (or more frequently if the dressing becomes soiled)

No information available to require special precautions

No effects or complications reported

Use exactly as directed; do not overuse. Wear gloves to apply a thin film to affected area. If dressing is necessary, use a porous dressing. Avoid contact with eyes. Report increased swelling, redness, rash, itching, signs of infection, worsening of condition, or lack of healing. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to be pregnant. Consult prescriber if breast-feeding.

Do not introduce into major body cavities; monitor debilitated patients for systemic bacterial infections

Ointment, topical: 250 units/g (15 g, 30 g)

Chamberlain TM, Cali TS, Cuzzell J, et al, "Assessment and Management of Pressure Sores in Long-Term Care Facilities," Consult Pharm, 1992, 7(12)1328-40.