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Pronunciation |
|
(koe
LIS
tin) |
|
|
U.S. Brand
Names |
|
Coly-Mycin® S
Oral |
|
|
Generic
Available |
|
No |
|
|
Synonyms |
|
Colistin Sulfate; Polymyxin E |
|
|
Pharmacological Index |
|
Antibiotic, Miscellaneous; Antidiarrheal |
|
|
Use |
|
Treatment of diarrhea in infants and children caused by susceptible
organisms, especially E. coli and Shigella, however, other
agents are preferred; treatment of superficial infections of external ear canal
and of mastoidectomy and fenestration cavities |
|
|
Pregnancy Risk
Factor |
|
C |
|
|
Contraindications |
|
Known hypersensitivity to colistin |
|
|
Warnings/Precautions |
|
Use with caution in patients with impaired renal function; some systemic
absorption may occur; potential for renal toxicity exists; prolonged use may
lead to superinfection |
|
|
Adverse
Reactions |
|
<1%: Neuromuscular blockade, nephrotoxicity, respiratory arrest, nausea,
vomiting, hypersensitivity reactions, superinfections |
|
|
Stability |
|
Stable for 2 weeks when refrigerated, shake well; discard after 14
days |
|
|
Mechanism of
Action |
|
Polypeptide antibiotic that binds to and damages the bacterial cell
membrane |
|
|
Pharmacodynamics/Kinetics |
|
Absorption: Oral: Slightly absorbed from GI tract (adults); unpredictable
absorption occurs in infants, can lead to significant serum levels
Half-life: 2.8-4.8 hours, prolonged in renal insufficiency; with anuria:
48-72 hours
Elimination: ~65% to 75% excreted unchanged in urine |
|
|
Usual Dosage |
|
Diarrhea: Children: Oral: 5-15 mg/kg/day in 3 divided doses given every 8
hours |
|
|
Mental Health: Effects
on Mental Status |
|
None reported |
|
|
Mental Health:
Effects on Psychiatric
Treatment |
|
None reported |
|
|
Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
|
No information available to require special precautions |
|
|
Dental Health:
Effects on Dental Treatment |
|
No effects or complications reported |
|
|
Patient
Information |
|
Keep refrigerated, shake well, discard after 14 days |
|
|
Dosage Forms |
|
Powder for oral suspension: 25 mg/5 mL (60
mL) |
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