Treat acute gouty arthritis attacks and prevent recurrences of such attacks,
management of familial Mediterranean fever
C (oral); D (parenteral)
Hypersensitivity to colchicine or any component; serious renal,
gastrointestinal, hepatic, or cardiac disorders; blood
Severe local irritation can occur following S.C. or I.M. administration; use
with caution in debilitated patients or elderly patients or patients with severe
GI, renal, or liver disease
>10%: Gastrointestinal: Nausea, vomiting, diarrhea, abdominal pain
1% to 10%:
<1%: Rash, azoospermia, agranulocytosis, aplastic anemia, bone marrow
suppression, hepatotoxicity, myopathy, peripheral neuritis
Symptoms of overdose include nausea, vomiting, abdominal pain, shock, kidney
damage, muscle weakness, burning in throat, watery to bloody diarrhea,
hypotension, anuria, cardiovascular collapse, delirium, convulsions
Treatment includes gastric lavage and measures to prevent shock, hemodialysis
or peritoneal dialysis; atropine and morphine may relieve abdominal pain
Decreased effect: Vitamin B12 absorption may be decreased
CNS depressant effects are enhanced
Protect tablets from light; I.V. colchicine is incompatible with I.V.
solutions with preservatives; incompatible with
Decreases leukocyte motility, decreases phagocytosis in joints and lactic
acid production, thereby reducing the deposition of urate crystals that
perpetuates the inflammatory response
Onset of effect: Oral: Pain relief begins within 12 hours if adequately dosed
Distribution: Concentrates in leukocytes, kidney, spleen, and liver; does not
distribute in heart, skeletal muscle, and brain
Protein binding: 10% to 31%
Metabolism: Partially deacetylated in the liver
Half-life: 12-30 minutes
End-stage renal disease: 45 minutes
Time to peak serum concentration: Oral: Within 0.5-2 hours declining for the
next 2 hours before increasing again due to enterohepatic recycling
Elimination: Primarily in the feces via bile; 10% to 20% excreted in the
Prophylaxis of familial Mediterranean fever: Oral:
less than or equal to 5 years: 0.5 mg/day
>5 years: 1-1.5 mg/day in 2-3 divided doses
Adults: 1-2 mg/day in 2-3 divided doses
Gouty arthritis, acute attacks: Adults:
Oral: Initial: 0.5-1.2 mg, then 0.5-0.6 mg every 1-2 hours or 1-1.2 mg every
2 hours until relief or GI side effects (nausea, vomiting, or diarrhea) occur to
a maximum total dose of 8 mg; wait 3 days before initiating another course of
I.V.: Initial: 1-3 mg, then 0.5 mg every 6 hours until response, not to
exceed 4 mg/day; if pain recurs, it may be necessary to administer a daily dose
of 1-2 mg for several days, however, do not administer more colchicine by any
route for at least 7 days after a full course of I.V. therapy (4 mg), transfer
to oral colchicine in a dose similar to that being given I.V.
Gouty arthritis, prophylaxis of recurrent attacks: Adults: Oral: 0.5-0.6
mg/day or every other day
Dosing adjustment in renal impairment:
Clcr <50 mL/minute: Avoid chronic use or administration
Clcr <10 mL/minute: Decrease dose by 50% for treatment of acute
Hemodialysis: Not dialyzable (0% to 5%); supplemental dose is not necessary
Peritoneal dialysis: Supplemental dose is not necessary
Alcohol: Avoid use
Food: Cyanocobalamin (Vitamin B12): Malabsorption of the
substrate. May result in macrocytic anemia or neurologic dysfunction. May need
to supplement with Vitamin B12.
CBC and renal function test
May cause false-positive results in urine tests for erythrocytes or
|Mental Health: Effects
on Mental Status|
May cause drowsiness
Effects on Psychiatric
Rare reports of agranulocytosis; use caution with clozapine and
carbamazepine; CNS depressant effects may be enhanced
|Dental Health: Local
No information available to require special precautions
Effects on Dental Treatment|
No effects or complications reported
Take as directed; do not exceed recommended dosage. Consult prescriber about
a low-purine diet. Maintain adequate hydration (2-3 L/day of fluids unless
instructed to restrict fluid intake). Do not use alcohol or aspirin-containing
medication without consulting prescriber. You may experience nausea, vomiting,
or anorexia (small frequent meals, frequent mouth care, chewing gum, or sucking
lozenges may help); hair loss (reversible). Stop medication and report to
prescriber if severe vomiting, watery or bloody diarrhea, or abdominal pain
occurs. Report muscle tremors or weakness; fatigue; easy bruising or bleeding;
yellowing of eyes or skin; or pale stool or dark urine.
Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend
to be pregnant. Consult prescriber if breast-feeding.
Severe local irritation can occur following S.C. or I.M. administration;
extravasation can cause tissue irritation; administer I.V. over 2-5 minutes into
tubing of free-flowing I.V. with compatible fluid; administer orally with water
and maintain adequate fluid intake
Injection: 0.5 mg/mL (2 mL)
Tablet: 0.5 mg, 0.6 mg
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