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Pronunciation |
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(kloe
KOR toe
lone) |
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U.S. Brand
Names |
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Cloderm®
Topical |
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Generic
Available |
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No |
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Synonyms |
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Clocortolone Pivalate |
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|
Pharmacological Index |
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Corticosteroid, Topical |
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|
Use |
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Inflammation of corticosteroid-responsive dermatoses (medium potency topical
corticosteroid) |
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Pregnancy Risk
Factor |
|
C |
|
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Contraindications |
|
Known hypersensitivity to clocortolone; viral, fungal, or tubercular skin
lesions |
|
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Warnings/Precautions |
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Adrenal suppression can occur if used for >14 days |
|
|
Adverse
Reactions |
|
1% to 10%:
Dermatologic: Itching, erythema
Local: Burning, dryness, irritation, papular rashes
<1%: Hypertrichosis, acneiform eruptions, maceration of skin, skin
atrophy, striae, hypopigmentation, perioral dermatitis, miliaria
|
|
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Drug
Interactions |
|
No data reported |
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|
Mechanism of
Action |
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Stimulates the synthesis of enzymes needed to decrease inflammation, suppress
mitotic activity, and cause vasoconstriction |
|
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Pharmacodynamics/Kinetics |
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Absorption: Percutaneous absorption is variable and dependent upon many
factors including vehicle used, integrity of epidermis, dose, and use of
occlusive dressings;
Distribution: Small amounts enter systemic circulation mostly throughout skin
Metabolism: Remains to be defined (largely in liver)
Elimination: In urine and bile |
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Usual Dosage |
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Adults: Apply sparingly and gently; rub into affected area from 1-4
times/day. Therapy should be discontinued when control is achieved; if no
improvement is seen, reassessment of diagnosis may be
necessary. |
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|
Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
|
No information available to require special precautions |
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|
Dental Health:
Effects on Dental Treatment |
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No effects or complications reported |
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Patient
Information |
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A thin film of cream or ointment is effective; do not overuse; do not use
tight-fitting diapers or plastic pants on children being treated in the diaper
area; use only as prescribed, and for no longer than the period prescribed;
apply sparingly in light film; rub in lightly; avoid contact with eyes; notify
physician if condition being treated persists or worsens |
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Nursing
Implications |
|
For external use only; do not use on open wounds; apply sparingly to
occlusive dressings; should not be used in the presence of open or weeping
lesions |
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Dosage Forms |
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Cream, as pivalate: 0.1% (15 g, 45
g) |
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