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Clocortolone
Pronunciation
U.S. Brand Names
Generic Available
Synonyms
Pharmacological Index
Use
Pregnancy Risk Factor
Contraindications
Warnings/Precautions
Adverse Reactions
Drug Interactions
Mechanism of Action
Pharmacodynamics/Kinetics
Usual Dosage
Dental Health: Local Anesthetic/Vasoconstrictor Precautions
Dental Health: Effects on Dental Treatment
Patient Information
Nursing Implications
Dosage Forms

Pronunciation
(kloe KOR toe lone)

U.S. Brand Names
Cloderm® Topical

Generic Available

No


Synonyms
Clocortolone Pivalate

Pharmacological Index

Corticosteroid, Topical


Use

Inflammation of corticosteroid-responsive dermatoses (medium potency topical corticosteroid)


Pregnancy Risk Factor

C


Contraindications

Known hypersensitivity to clocortolone; viral, fungal, or tubercular skin lesions


Warnings/Precautions

Adrenal suppression can occur if used for >14 days


Adverse Reactions

1% to 10%:

Dermatologic: Itching, erythema

Local: Burning, dryness, irritation, papular rashes

<1%: Hypertrichosis, acneiform eruptions, maceration of skin, skin atrophy, striae, hypopigmentation, perioral dermatitis, miliaria


Drug Interactions

No data reported


Mechanism of Action

Stimulates the synthesis of enzymes needed to decrease inflammation, suppress mitotic activity, and cause vasoconstriction


Pharmacodynamics/Kinetics

Absorption: Percutaneous absorption is variable and dependent upon many factors including vehicle used, integrity of epidermis, dose, and use of occlusive dressings;

Distribution: Small amounts enter systemic circulation mostly throughout skin

Metabolism: Remains to be defined (largely in liver)

Elimination: In urine and bile


Usual Dosage

Adults: Apply sparingly and gently; rub into affected area from 1-4 times/day. Therapy should be discontinued when control is achieved; if no improvement is seen, reassessment of diagnosis may be necessary.


Dental Health: Local Anesthetic/Vasoconstrictor Precautions

No information available to require special precautions


Dental Health: Effects on Dental Treatment

No effects or complications reported


Patient Information

A thin film of cream or ointment is effective; do not overuse; do not use tight-fitting diapers or plastic pants on children being treated in the diaper area; use only as prescribed, and for no longer than the period prescribed; apply sparingly in light film; rub in lightly; avoid contact with eyes; notify physician if condition being treated persists or worsens


Nursing Implications

For external use only; do not use on open wounds; apply sparingly to occlusive dressings; should not be used in the presence of open or weeping lesions


Dosage Forms

Cream, as pivalate: 0.1% (15 g, 45 g)


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