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Pronunciation |
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(kloe
BAY ta
sol) |
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U.S. Brand
Names |
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Cormax® Ointment;
Temovate® |
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Generic
Available |
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Yes |
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Canadian Brand
Names |
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Dermasone; Dermovate®; Gen-Clobetasol;
Novo-Clobetasol |
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Synonyms |
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Clobetasol Propionate |
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Pharmacological Index |
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Corticosteroid, Topical |
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Use |
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Short-term relief of inflammation of moderate to severe
corticosteroid-responsive dermatosis (very high potency topical
corticosteroid) |
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Pregnancy Risk
Factor |
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C |
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Contraindications |
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Known hypersensitivity to clobetasol; viral, fungal, or tubercular skin
lesions |
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Warnings/Precautions |
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Adrenal suppression can occur if used for >14 days. Topical foam is not
for use in children <12 years of age. Topical foam should not be used with
occlusive dressings unless directed by healthcare provider. |
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Adverse
Reactions |
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1% to 10%:
Dermatologic: Itching, erythema,
Local: Burning, dryness, irritation, papular rashes
<1%: Hypertrichosis, acneiform eruptions, maceration of skin, skin
atrophy, striae, hypopigmentation, perioral dermatitis, miliaria, eczema (foam),
skin hypertrophy (foam) |
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Drug
Interactions |
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No data reported |
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Mechanism of
Action |
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Stimulates the synthesis of enzymes needed to decrease inflammation, suppress
mitotic activity, and cause vasoconstriction |
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Pharmacodynamics/Kinetics |
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Absorption: Percutaneous absorption variable and dependent upon many factors
including vehicle used, integrity of epidermis, dose, and use of occlusive
dressings
Metabolism: Remains to be defined
Elimination: In urine and bile |
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Usual Dosage |
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Adults: Topical:
Foam: Scalp: Apply to affected scalp twice daily for up to 2 weeks ( less
than or equal to 50 g/week) |
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Mental Health: Effects
on Mental Status |
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None reported |
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Mental Health:
Effects on Psychiatric
Treatment |
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None reported |
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Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
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No information available to require special precautions |
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Dental Health:
Effects on Dental Treatment |
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No effects or complications reported |
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Patient
Information |
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A thin film of cream or ointment is effective; do not overuse; do not use
tight-fitting diapers or plastic pants on children being treated in the diaper
area; use only as prescribed and for no longer than the period prescribed; apply
sparingly in light film; rub in lightly; avoid contact with eyes; notify
physician if condition being treated persists or worsens; to apply foam, hold
can upside down and apply directly to scalp; gently massage foam into affected
area until foam disappears |
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Nursing
Implications |
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For external use only; do not use on open wounds; apply sparingly to
occlusive dressings; should not be used in the presence of open or weeping
lesions; do not use occlusive dressings with foam unless directed by healthcare
provider |
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Dosage Forms |
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Cream, as propionate: 0.05% (15 g, 30 g, 45 g)
Cream, as propionate, in emollient base: 0.05% (15 g, 30 g, 60 g)
Gel, as propionate: 0.05% (15 g, 30 g, 45 g)
Ointment, topical, as propionate: 0.05% (15 g, 30 g, 45 g)
Scalp application, as propionate: 0.05% (25 mL, 50 mL)
Foam (Olux™): 0.05% (100 g)
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