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Clobetasol
Pronunciation
U.S. Brand Names
Generic Available
Canadian Brand Names
Synonyms
Pharmacological Index
Use
Pregnancy Risk Factor
Contraindications
Warnings/Precautions
Adverse Reactions
Drug Interactions
Mechanism of Action
Pharmacodynamics/Kinetics
Usual Dosage
Mental Health: Effects on Mental Status
Mental Health: Effects on Psychiatric Treatment
Dental Health: Local Anesthetic/Vasoconstrictor Precautions
Dental Health: Effects on Dental Treatment
Patient Information
Nursing Implications
Dosage Forms

Pronunciation
(kloe BAY ta sol)

U.S. Brand Names
Cormax® Ointment; Temovate®

Generic Available

Yes


Canadian Brand Names
Dermasone; Dermovate®; Gen-Clobetasol; Novo-Clobetasol

Synonyms
Clobetasol Propionate

Pharmacological Index

Corticosteroid, Topical


Use

Short-term relief of inflammation of moderate to severe corticosteroid-responsive dermatosis (very high potency topical corticosteroid)


Pregnancy Risk Factor

C


Contraindications

Known hypersensitivity to clobetasol; viral, fungal, or tubercular skin lesions


Warnings/Precautions

Adrenal suppression can occur if used for >14 days. Topical foam is not for use in children <12 years of age. Topical foam should not be used with occlusive dressings unless directed by healthcare provider.


Adverse Reactions

1% to 10%:

Dermatologic: Itching, erythema,

Local: Burning, dryness, irritation, papular rashes

<1%: Hypertrichosis, acneiform eruptions, maceration of skin, skin atrophy, striae, hypopigmentation, perioral dermatitis, miliaria, eczema (foam), skin hypertrophy (foam)


Drug Interactions

No data reported


Mechanism of Action

Stimulates the synthesis of enzymes needed to decrease inflammation, suppress mitotic activity, and cause vasoconstriction


Pharmacodynamics/Kinetics

Absorption: Percutaneous absorption variable and dependent upon many factors including vehicle used, integrity of epidermis, dose, and use of occlusive dressings

Metabolism: Remains to be defined

Elimination: In urine and bile


Usual Dosage

Adults: Topical:

Foam: Scalp: Apply to affected scalp twice daily for up to 2 weeks ( less than or equal to 50 g/week)


Mental Health: Effects on Mental Status

None reported


Mental Health: Effects on Psychiatric Treatment

None reported


Dental Health: Local Anesthetic/Vasoconstrictor Precautions

No information available to require special precautions


Dental Health: Effects on Dental Treatment

No effects or complications reported


Patient Information

A thin film of cream or ointment is effective; do not overuse; do not use tight-fitting diapers or plastic pants on children being treated in the diaper area; use only as prescribed and for no longer than the period prescribed; apply sparingly in light film; rub in lightly; avoid contact with eyes; notify physician if condition being treated persists or worsens; to apply foam, hold can upside down and apply directly to scalp; gently massage foam into affected area until foam disappears


Nursing Implications

For external use only; do not use on open wounds; apply sparingly to occlusive dressings; should not be used in the presence of open or weeping lesions; do not use occlusive dressings with foam unless directed by healthcare provider


Dosage Forms

Cream, as propionate: 0.05% (15 g, 30 g, 45 g)

Cream, as propionate, in emollient base: 0.05% (15 g, 30 g, 60 g)

Gel, as propionate: 0.05% (15 g, 30 g, 45 g)

Ointment, topical, as propionate: 0.05% (15 g, 30 g, 45 g)

Scalp application, as propionate: 0.05% (25 mL, 50 mL)

Foam (Olux™): 0.05% (100 g)


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