No

Antihistamine

Perennial and seasonal allergic rhinitis and other allergic symptoms including urticaria

C

Narrow-angle glaucoma, hypersensitivity to clemastine or any component

Safety and efficacy have not been established in children <6 years of age; bladder neck obstruction, symptomatic prostate hypertrophy, asthmatic attacks, and stenosing peptic ulcer

>10%:

Central nervous system: Slight to moderate drowsiness

Respiratory: Thickening of bronchial secretions

1% to 10%:

Central nervous system: Headache, fatigue, nervousness, increased dizziness

Gastrointestinal: Appetite increase, weight gain, nausea, diarrhea, abdominal pain, xerostomia

Neuromuscular & skeletal: Arthralgia

Respiratory: Pharyngitis

<1%: Edema, palpitations, depression, angioedema, photosensitivity, rash, hepatitis, myalgia, paresthesia, bronchospasm, epistaxis

Symptoms of overdose include anemia, metabolic acidosis, hypotension, hypothermia

There is no specific treatment for an antihistamine overdose, however, most of its clinical toxicity is due to anticholinergic effects. For anticholinergic overdose with severe life-threatening symptoms, physostigmine 1-2 mg (0.5 mg or 0.02 mg/kg for children) I.V., slowly may be given to reverse these effects.

Increased toxicity (CNS depression): CNS depressants, MAO inhibitors, tricyclic antidepressants, phenothiazines

Competes with histamine for H₁-receptor sites on effector cells in the gastrointestinal tract, blood vessels, and respiratory tract

Duration: 8-16 hours

Peak therapeutic effect: Within 5-7 hours

Absorption: Almost 100% from GI tract

Metabolism: In the liver

Elimination: In urine

Oral:

Children >12 years and Adults: 1.34 mg twice daily to 2.68 mg 3 times/day; do not exceed 8.04 mg/day; lower doses should be considered in patients >60 years

Alcohol: Additive CNS effects, avoid use

Look for a reduction of rhinitis, urticaria, eczema, pruritus, or other allergic symptoms

Drowsiness is common; may cause nervousness; rare reports of depression

Concurrent use with psychotropics may result in additive sedation

No information available to require special precautions

No effects or complications reported

Avoid alcohol; may cause drowsiness, may impair coordination or judgment

Raise bed rails, institute safety measures, assist with ambulation

Syrup, as fumarate (citrus flavor): 0.67 mg/5 mL with alcohol 5.5% (120 mL)

Tablet, as fumarate: 1.34 mg, 2.68 mg