Yes

Ovulation Stimulator

Induces ovulation and pregnancy in anovulatory, infertile females; treatment of hypogonadotropic hypogonadism, prepubertal cryptorchidism

C

Hypersensitivity to chorionic gonadotropin or any component; precocious puberty, prostatic carcinoma or similar neoplasms

Use with caution in asthma, seizure disorders, migraine, cardiac or renal disease; not effective in the treatment of obesity

1% to 10%:

Central nervous system: Mental depression, fatigue

Endocrine & metabolic: Pelvic pain, ovarian cysts, enlargement of breasts, precocious puberty

Local: Pain at the injection site

Neuromuscular & skeletal: Premature closure of epiphyses

<1%: Peripheral edema, irritability, restlessness, headache, ovarian hyperstimulation syndrome, gynecomastia

No data reported

Following reconstitution with the provided diluent, solutions are stable for 30-90 days, depending on the specific preparation, when stored at 2°C to 15°C

Stimulates production of gonadal steroid hormones by causing production of androgen by the testis; as a substitute for luteinizing hormone (LH) to stimulate ovulation

Half-life, biphasic: Initial: 11 hours; Terminal: 23 hours

Elimination: Excreted unchanged in urine within 3-4 days

I.M.:

Prepubertal cryptorchidism: 1000-2000 units/m²/dose 3 times/week for 3 weeks OR 4000 units 3 times/week for 3 weeks OR 5000 units every second day for 4 injections OR 500 units 3 times/week for 4-6 weeks

Hypogonadotropic hypogonadism: 500-1000 units 3 times/week for 3 weeks, followed by the same dose twice weekly for 3 weeks OR 1000-2000 units 3 times/week OR 4000 units 3 times/week for 6-9 months; reduce dosage to 2000 units 3 times/week for additional 3 months

Adults: Induction of ovulation: 5000-10,000 units one day following last dose of menotropins

Give I.M. only

Depends on application and methodology; <3 mIU/mL (SI: <3 units/L) usually normal (nonpregnant)

May cause drowsiness or depression; rarely may cause restlessness or irritability

None reported

No information available to require special precautions

No effects or complications reported

Discontinue immediately if possibility of pregnancy

Powder for injection (human origin): 200 units/mL (10 mL, 25 mL); 500 units/mL (10 mL); 1000 units/mL (10 mL); 2000 units/mL (10 mL)