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| Pronunciation |
 (kon
DROY tin SUL fate-SOW de um hye
al yoor ON ate) |
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| U.S. Brand Names |
| Viscoat® |
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| Generic Available |
|
No |
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| Synonyms |
| Sodium Hyaluronate-Chrondroitin Sulfate |
|
| Pharmacological Index |
|
Ophthalmic Agent, Viscoelastic |
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| Use |
|
Surgical aid in anterior segment procedures, protects corneal endothelium and coats intraocular lens thus protecting it |
|
| Pregnancy Risk Factor |
|
C |
|
| Contraindications |
|
Hypersensitivity to hyaluronate |
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| Warnings/Precautions |
|
Product is extracted from avian tissues and contains minute amounts of protein, potential risks of hypersensitivity may exist. Intraocular pressure may be elevated as a result of pre-existing glaucoma, compromised outflow and by operative procedures and sequelae, including coma, compromised outflow and by operative procedures and sequelae, including enzymatic zonulysis, absence of an iridectomy, trauma to filtration structures and by blood and lenticular remnants in the anterior chamber. Monitor IOP, especially during the immediate postoperative period. |
|
| Adverse Reactions |
|
1% to 10%: Ocular: Increased intraocular pressure |
|
| Stability |
|
Store at 2°C to 8°C/36°F to 46°F; do not freeze |
|
| Mechanism of Action |
|
Functions as a tissue lubricant and is thought to play an important role in modulating the interactions between adjacent tissues |
|
| Pharmacodynamics/Kinetics |
|
Absorption: Following intravitreous injection, diffusion occurs slowly Elimination: By way of the Canal of Schlemm |
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| Usual Dosage |
|
Carefully introduce (using a 27-gauge needle or cannula) into anterior chamber after thoroughly cleaning the chamber with a balanced salt solution |
|
| Administration |
|
May inject prior to or following delivery of the crystalline lens. Instillation prior to lens delivery provides additional protection to corneal endothelium, protecting it from possible damage arising from surgical instrumentation. May also be used to coat intraocular lens and tips of surgical instruments prior to implantation surgery. May inject additional solution during anterior segment surgery to fully maintain the solution lost during surgery. At the end of surgery, remove solution by thoroughly irrigating with a balanced salt solution. |
|
| Test Interactions |
|
False-negative results for Clinistix® urine test; false-positive results with Clinitest® |
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| Dental Health: Local Anesthetic/Vasoconstrictor Precautions |
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No information available to require special precautions |
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| Dental Health: Effects on Dental Treatment |
|
No effects or complications reported |
|
| Dosage Forms |
|
Solution: Sodium chondroitin 40 mg and sodium hyaluronate 30 mg (0.25 mL, 0.5 mL) |
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