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Pronunciation |
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(KOL
er a vak
SEEN) |
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Generic
Available |
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No |
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Pharmacological Index |
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Vaccine |
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Use |
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The World Health Organization no longer recommends cholera vaccination for
travel to or from cholera-endemic areas. Some countries may still require
evidence of a complete primary series or a booster dose given within 6 months of
arrival. Vaccination should not be considered as an alternative to continued
careful selection of foods and water. Ideally, cholera and yellow fever vaccines
should be administered at least 3 weeks apart. |
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Pregnancy Risk
Factor |
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C |
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Contraindications |
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Presence of any acute illness, history of severe systemic reaction, or
allergic response following a prior dose of cholera vaccine |
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Warnings/Precautions |
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There is no data on the safety of cholera vaccination during pregnancy. Use
in pregnancy should reflect actual increased risk. Persons who have had severe
local or systemic reactions to a previous dose should not be revaccinated. Have
epinephrine (1:1000) available for immediate use. |
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Adverse
Reactions |
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All serious adverse reactions must be reported to the U.S. Department of
Health and Human Services (DHHS) Vaccine Adverse Event Reporting System (VAERS)
1-800-822-7967.
Central nervous system: Malaise, fever, headache
Local: Pain, edema, tenderness, erythema, and induration at injection site
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Drug
Interactions |
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Decreased effect with yellow fever vaccine; data suggests that giving both
vaccines within 3 weeks of each other may decrease the response to
both |
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Stability |
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Refrigerate, avoid freezing |
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Mechanism of
Action |
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Inactivated vaccine producing active immunization |
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Usual Dosage |
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Children:
6 months to 4 years: Two 0.2 mL doses I.M./S.C. 1 week to 1 month apart;
booster doses (0.2 mL I.M./S.C.) every 6 months
5-10 years: Two 0.3 mL doses I.M./S.C. or two 0.2 mL intradermal doses 1 week
to 1 month apart; booster doses (0.3 mL I.M./S.C. or 0.2 mL I.D.) every 6 months
Children greater than or equal to 10 years and Adults: Two 0.5 mL doses given
I.M./S.C. or two 0.2 mL doses I.D. 1 week to 1 month apart; booster doses (0.5
mL I.M. or S.C. or 0.2 mL I.D.) every 6 months |
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Administration |
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Do not give I.V. |
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Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
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No information available to require special precautions |
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Dental Health:
Effects on Dental Treatment |
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No effects or complications reported |
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Patient
Information |
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Local reactions can occur up to 7 days after injection |
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Nursing
Implications |
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Defer immunization in individuals with moderate or severe febrile
illness |
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Dosage Forms |
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Injection: Suspension of killed Vibrio cholerae (Inaba and Ogawa
types) 8 units of each serotype per mL (1.5 mL, 20
mL) |
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