Yes

Skeletal Muscle Relaxant

Dental: Treatment of muscle spasm with acute temporomandibular joint pain

Medical: Symptomatic treatment of muscle spasm and pain associated with acute musculoskeletal conditions

C

Known hypersensitivity to chlorzoxazone; impaired liver function

>10%: Central nervous system: Drowsiness

1% to 10%:

Cardiovascular: Tachycardia, tightness in chest, flushing of face, syncope

Central nervous system: Mental depression, allergic fever, dizziness, lightheadedness, headache, paradoxical stimulation

Dermatologic: Angioedema

Gastrointestinal: Nausea, vomiting, stomach cramps

Neuromuscular & skeletal: Trembling

Ocular: Burning of eyes

Respiratory: Shortness of breath

Miscellaneous: Hiccups

<1%: Ataxia, rash, urticaria, erythema multiforme, aplastic anemia, leukopenia, eosinophilia, blurred vision

Symptoms of overdose include nausea, vomiting, diarrhea, drowsiness, dizziness, headache, absent tendon reflexes, hypotension

Treatment is supportive following attempts to enhance drug elimination. Hypotension should be treated with I.V. fluids and/or Trendelenburg positioning. Dialysis and hemoperfusion and osmotic diuresis have all been useful in reducing serum drug concentrations; patient should be observed for possible relapses due to incomplete gastric emptying.

CYP2E1 enzyme substrate

Acts on the spinal cord and subcortical levels by depressing polysynaptic reflexes

Onset of action: Within 1 hour

Duration: 6-12 hours

Absorption: Oral: Readily absorbed

Metabolism: Extensively in the liver by glucuronidation

Elimination: Excretion in urine as conjugates

Oral:

Adults: 250-500 mg 3-4 times/day up to 750 mg 3-4 times/day

Alcohol: Additive CNS effects, avoid use

Periodic liver functions tests

Drowsiness is common; may produce depression or paradoxical stimulation

May produce aplastic anemia and leukopenia; use caution with clozapine and carbamazepine

No information available to require special precautions

No effects or complications reported

Take exactly as directed, with food. Do not increase dose or discontinue without consulting prescriber. Do not use alcohol, prescriptive or OTC antidepressants, sedatives, or pain medications without consulting prescriber. May turn urine orange or red (normal). You may experience drowsiness, dizziness, lightheadedness (avoid driving or engaging in tasks that require alertness until response to drug is known); nausea, vomiting, or cramping (small, frequent meals, frequent mouth care, or sucking hard candy may help); postural hypotension (change position slowly when rising from sitting or lying or when climbing stairs); or constipation (increased dietary fluids and fibers or increased exercise may help). Report excessive drowsiness or mental agitation; palpitations, rapid heartbeat, or chest pain; skin rash or swelling of mouth or face; persistent diarrhea or constipation; or unusual weakness or bleeding. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to be pregnant. Breast-feeding is not recommended.

Raise bed rails; institute safety measures; assist with ambulation

Caplet (Parafon Forte™ DSC): 500 mg

Capsule (Flexaphen®, Mus-Lax®): 250 mg with acetaminophen 300 mg

Tablet: Paraflex®: 250 mg