Yes

Skeletal Muscle Relaxant

Dental: Treatment of muscle spasm associated with acute temporomandibular joint pain

Medical: Skeletal muscle relaxant

C

Acute intermittent porphyria, hypersensitivity to carisoprodol, meprobamate or any component

Use with caution in renal and hepatic dysfunction

>10%: Central nervous system: Drowsiness

1% to 10%:

Cardiovascular: Tachycardia, tightness in chest, flushing of face, syncope

Central nervous system: Mental depression, allergic fever, dizziness, lightheadedness, headache, paradoxical CNS stimulation

Dermatologic: Angioedema

Gastrointestinal: Nausea, vomiting, stomach cramps

Neuromuscular & skeletal: Trembling

Ocular: Burning eyes

Respiratory: Shortness of breath

Miscellaneous: Hiccups

<1%: Ataxia, rash, urticaria, erythema multiforme, aplastic anemia, leukopenia, eosinophilia, blurred vision

Symptoms of overdose include CNS depression, stupor, coma, shock, respiratory depression

Treatment is supportive following attempts to enhance drug elimination. Hypotension should be treated with I.V. fluids and/or Trendelenburg positioning.

CYP2C19 enzyme substrate

Precise mechanism is not yet clear, but many effects have been ascribed to its central depressant actions

Onset of action: Within 30 minutes

Duration: 4-6 hours

Distribution: Crosses the placenta; appears in high concentrations in breast milk

Metabolism: By the liver

Half-life: 8 hours

Elimination: By the kidneys

Adults: Oral: 350 mg 3-4 times/day; take last dose at bedtime; compound: 1-2 tablets 4 times/day

Alcohol: Additive CNS effects, avoid use

Look for relief of pain and/or muscle spasm and avoid excessive drowsiness

Drowsiness is common; may produce depression or paradoxical CNS stimulation

Rarely may cause leukopenia or aplastic anemia; use caution with clozapine and carbamazepine; concurrent use with psychotropics may produce additive sedation

No information available to require special precautions

No effects or complications reported

Take exactly as directed with food. Do not increase dose or discontinue without consulting prescriber. Do not use alcohol, prescriptive or OTC antidepressants, sedatives, and pain medications without consulting prescriber. You may experience drowsiness, dizziness, lightheadedness (avoid driving or engaging in tasks requiring alertness until response to drug is known); nausea, vomiting, or cramping (small, frequent meals, frequent mouth care, or sucking hard candy may help); or postural hypotension (change position slowly when rising from sitting or lying or when climbing stairs). Report excessive drowsiness or mental agitation; palpitations, rapid heartbeat, or chest pain; skin rash; muscle cramping or tremors; or respiratory difficulty. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to be pregnant. Breast-feeding is not recommended.

Raise bed rails; institute safety measures; assist with ambulation

Tablet: 350 mg

A suspension can be prepared by triturating 60 carisoprodol 350 mg tablets, a small amount of water or glycerin, then mixing with a sufficient quantity of cherry syrup to bring the final volume to 60 mL; when refrigerated, the suspension is stable for 14 days; shake well before administration

Adams HR, Kerzee T, and Morehead CD, "Carisoprodol-Related Death in a Child," J Forensic Sci, 1975, 20:200-2.

Backer RC, Zumwalt R, McFeeley P, et al, "Carisoprodol Concentrations From Different Anatomical Sites: Three Overdose Cases," J Anal Toxicol, 1990, 14(5):332-4.

Goldberg D, "Carisoprodol Toxicity," Milit Med, 1969, 34:597-601.

Luehr JG, Meyerle KA, and Larson EW, "Mail-Order (Veterinary) Drug Dependence," JAMA, 1990, 263(5):657.