No

Cholinergic Agonist; Ophthalmic Agent, Antiglaucoma; Ophthalmic Agent, Miotic

Lowers intraocular pressure in the treatment of glaucoma; cause miosis during surgery

C

Acute iritis, acute inflammatory disease of the anterior chamber, hypersensitivity to carbachol or any component

Use with caution in patients undergoing general anesthesia and in presence of corneal abrasion

1% to 10%: Ocular: Blurred vision, eye pain

<1%: Transient fall in blood pressure, headache, stomach cramps, diarrhea, ciliary spasm with temporary decrease of visual acuity, corneal clouding, persistent bullous keratopathy, postoperative keratitis, retinal detachment, transient ciliary and conjunctival injection, asthma, increased peristalsis

Symptoms of overdose include miosis, flushing, vomiting, bradycardia, bronchospasm, involuntary urination

Atropine is the treatment of choice for intoxications manifesting with significant muscarinic symptoms. Atropine I.V. 2-4 mg every 3-60 minutes (or 0.04-0.08 mg I.V. every 5-60 minutes if needed for children) should be repeated to control symptoms and then continued as needed for 1-2 days following the acute ingestion. Epinephrine 0.1-1 mg S.C. may be useful in reversing severe cardiovascular or pulmonary sequelae.

Decreased effect of carbachol possible with topical NSAIDs

Intraocular: Store at room temperature of 15°C to 30°C/59°F to 86°F

Topical: Store at 8°C to 27°C/46°F to 80°F

Synthetic direct-acting cholinergic agent that causes miosis by stimulating muscarinic receptors in the eye

Ophthalmic instillation:

Onset of miosis: 10-20 minutes

Duration of reduction in intraocular pressure: 4-8 hours

Intraocular administration:

Onset of miosis: Within 2-5 minutes

Duration: 24 hours

Adults:

Intraocular: 0.5 mL instilled into anterior chamber before or after securing sutures

None reported

None reported

No information available to require special precautions

Ophthalmic use of carbachol has no effect on dental treatment

May sting on instillation; may cause headache, altered distance vision, and decreased night vision

Finger pressure should be applied on the lacrimal sac for 1-2 minutes following topical instillation; remove excess around the eye with a tissue. Instillation for miosis prior to eye surgery should be gentle and parallel to the iris face and tangential to the pupil border; discard unused portion.

Solution:

Topical, ophthalmic:

Carboptic®: 3% (15 mL)

Isopto® Carbachol: 0.75% (15 mL, 30 mL); 1.5% (15 mL, 30 mL); 2.25% (15 mL); 3% (15 mL, 30 mL)