|
Pronunciation |
|
(byoo
toe KOE na
zole) |
|
|
Generic
Available |
|
No |
|
|
Synonyms |
|
Butoconazole Nitrate |
|
|
Pharmacological Index |
|
Antifungal Agent, Vaginal |
|
|
Use |
|
Local treatment of vulvovaginal candidiasis |
|
|
Pregnancy Risk
Factor |
|
C (For use only in 2nd or 3rd trimester) |
|
|
Contraindications |
|
Known hypersensitivity to butoconazole |
|
|
Warnings/Precautions |
|
In pregnancy, use only during 2nd or 3rd trimesters; if irritation or
sensitization occurs, discontinue use |
|
|
Adverse
Reactions |
|
1% to 10%: Genitourinary: Vulvar/vaginal burning
<1%: Vulvar itching, soreness, edema, or discharge; polyuria
|
|
|
Drug
Interactions |
|
No data reported |
|
|
Stability |
|
Do not store at temperatures
>40°C/104°F; avoid
freezing |
|
|
Mechanism of
Action |
|
Increases cell membrane permeability in susceptible fungi (
Candida) |
|
|
Pharmacodynamics/Kinetics |
|
Absorption: Following intravaginal application small amounts of drug are
absorbed systemically (25%) within 2-8 hours
Half-life: 21-24 hours
Elimination: Into urine and feces in approximate equal amounts
|
|
|
Usual Dosage |
|
Adults:
Pregnant: Use only during 2nd or 3rd trimester |
|
|
Mental Health: Effects
on Mental Status |
|
None reported |
|
|
Mental Health:
Effects on Psychiatric
Treatment |
|
None reported |
|
|
Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
|
No information available to require special precautions |
|
|
Dental Health:
Effects on Dental Treatment |
|
No effects or complications reported |
|
|
Patient
Information |
|
May cause burning or stinging on application; if symptoms of vaginitis
persist, contact physician |
|
|
Nursing
Implications |
|
May cause burning or stinging on application; if symptoms of vaginitis
persist, contact physician |
|
|
Dosage Forms |
|
Cream, vaginal, as nitrate: 2% with applicator (28
g) |
|
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|