No

Antifungal Agent, Topical

Topical treatment of tinea pedis (athlete's foot) and tinea cruris (jock itch)

B

Hypersensitivity to butenafine or components

Only for topical use (not ophthalmic, vaginal, or internal routes); patients sensitive to other allylamine antifungals may cross-react with butenafine

>1%: Dermatologic: Burning, stinging, irritation, erythema, pruritus (2%)

<1%: Contact dermatitis

Butenafine exerts antifungal activity by blocking squalene epoxidation, resulting in inhibition of ergosterol synthesis (antidermatophyte and Sporothrix schenckii activity). In higher concentrations, the drug disrupts fungal cell membranes (anticandidal activity).

Absorption: Minimal systemic absorption when topically applied

Metabolism: Hepatic; principle metabolite via hydroxylation

Half-life: 35 hours

Time to peak serum concentration: 6 hours (10 ng/mL)

Children >12 years and Adults: Topical: Apply once daily for 4 weeks to the affected area and surrounding skin

Culture and KOH exam, clinical signs of tinea pedis

None reported

None reported

No information available to require special precautions

No effects or complications reported

Report any signs of rash or allergy to your physician immediately; do not apply other topical medications on the same area as butenafine unless directed by your physician

Cream, as hydrochloride: 1% (2 g, 15 g, 30 g)

Greer DL, Weiss J, Rodriguez DA, et al, "A Randomized Trial to Assess Once-Daily Topical Treatment of Tinea Corporis With Butenafine, a New Antifungal Agent," J Am Acad Dermatol, 1997, 37(2 Pt 1):231-5.

McNeely W and Spencer CM, "Butenafine," Drugs, 1998, 55(3):405-12.

Reyes BA, Beutner KR, Cullen SI, et al, "Butenafine, a Fungicidal Benzylamine Derivative, Used Once Daily for the Treatment of Interdigital Tinea Pedis," Int J Dermatol, 1998, 37(6):450-3.

Syed TA, Ahmadpour OA, Ahmad SA, et al, "Management of Toenail Onychomycosis With 2% Butenafine and 20% Urea Cream: A Placebo-Controlled, Double-Blind Study," J Dermatol, 1998, 25(10):648-52.

"Topical Butenafine for Tinea Pedis," Med Lett Drugs Ther, 1997, 39(1004):63-4.

Tschen E, Elewski B, Gorsulowsky DC, et al, "Treatment of Interdigital Tinea Pedis With a 4-Week Once-Daily Regimen of Butenafine Hydrochloride 1% Cream," J Am Acad Dermatol, 1997, 36(2 Pt 1):S9-14.