Yes

Antihistamine

Prevention and treatment of motion sickness; symptomatic treatment of vertigo

C

Known hypersensitivity to buclizine

Product contains tartrazine; use with caution in patients with angle-closure glaucoma, peptic ulcer, urinary tract obstruction, hyperthyroidism; some preparations contain sodium bisulfite; syrup contains alcohol

>10%: Central nervous system: Drowsiness

<1%: Hypotension, palpitations, sedation, dizziness, paradoxical excitement, fatigue, insomnia, nausea, vomiting, urinary retention, tremor, blurred vision

CNS stimulation or depression; overdose may result in death in infants and children

There is no specific treatment for an antihistamine overdose, however, most of its clinical toxicity is due to anticholinergic effects; anticholinesterase inhibitors including physostigmine, neostigmine, pyridostigmine, and edrophonium may be useful by reducing acetylcholinesterase; for anticholinergic overdose with severe life-threatening symptoms, physostigmine 1-2 mg (0.5 mg or 0.02 mg/kg for children) I.V., slowly may be given to reverse these effects

Increased toxicity: CNS depressants, MAO inhibitors, tricyclic antidepressants

Buclizine acts centrally to suppress nausea and vomiting. It is a piperazine antihistamine closely related to cyclizine and meclizine. It also has CNS depressant, anticholinergic, antispasmodic, and local anesthetic effects, and suppresses labyrinthine activity and conduction in vestibular-cerebellar nerve pathways.

Adults: Oral:

Vertigo: 50 mg twice daily, up to 150 mg/day

Drowsiness is common

Concurrent use with psychotropics may produce additive sedation

Take as directed. Do not increase dose or take more often than recommended. May cause drowsiness; use caution when driving or engaging in tasks that require alertness until response to drug is known. May cause dry mouth; lozenges, gum, or liquids may help. May cause headache or feelings of jitteriness or anxiety; these will go away when drug is discontinued. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to be pregnant. Do not breast-feed.

Bucladin®-S Softab® may be chewed, swallowed whole, or allowed to dissolve in mouth

Tablet, chewable, as hydrochloride: 50 mg

Atkinson R and Appenzeller O, "Headache," Postgrad Med J, 1984, 60(710):841-6.