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| Pronunciation |
 (brome
fen IR a meen & soo doe e
FED rin) |
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| U.S. Brand Names |
| Brofed® Elixir [OTC]; Bromfed® Syrup [OTC]; Bromfed® Tablet [OTC]; Bromfenex®; Bromfenex® PD; Drixoral® Syrup [OTC]; Iofed®; Iofed® PD |
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| Generic Available |
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Yes |
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| Pharmacological Index |
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Antihistamine/Decongestant Combination |
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| Use |
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Temporary relief of symptoms of seasonal and perennial allergic rhinitis, and vasomotor rhinitis, including nasal obstruction |
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| Pregnancy Risk Factor |
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C |
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| Adverse Reactions |
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>10%: Cardiovascular: Tachycardia Central nervous system: Slight to moderate drowsiness, nervousness, transient stimulation, insomnia Respiratory: Thickening of bronchial secretions 1% to 10%: Central nervous system: Headache, fatigue, dizziness Gastrointestinal: Appetite increase, weight increase, nausea, diarrhea, abdominal pain, dry mouth Genitourinary: Dysuria Neuromuscular & skeletal: Arthralgia, weakness Respiratory: Pharyngitis Miscellaneous: Sweating <1%: Cardiovascular: Edema, palpitations, hypotension Central nervous system: Depression, sedation, paradoxical excitement, convulsions, hallucinations Dermatologic: Angioedema, rash, photosensitivity Genitourinary: Urinary retention Hepatic: Hepatitis Neuromuscular & skeletal: Myalgia, paresthesia, tremor Ocular: Blurred vision Respiratory: Bronchospasm, epistaxis, dyspnea |
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| Drug Interactions |
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CNS depressants, MAO inhibitors, sympathomimetics, Rauwolfia alkaloids, tricyclic antidepressants, ganglionic blocking agents, propranolol |
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| Usual Dosage |
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Children >12 years and Adults: Oral: 10 mL every 4-6 hours, up to 40 mL/day |
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| Dental Health: Local Anesthetic/Vasoconstrictor Precautions |
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Use with caution since pseudoephedrine is a sympathomimetic amine which could interact with epinephrine to cause a pressor response |
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| Dental Health: Effects on Dental Treatment |
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Brompheniramine: Prolonged use may decrease salivary flow Pseudoephedrine: Up to 10% of patients could experience tachycardia, palpitations, and dry mouth; use vasoconstrictor with caution |
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| Dosage Forms |
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Capsule, extended release: Bromfenex® PD, Iofed® PD: Brompheniramine maleate 6 mg and pseudoephedrine hydrochloride 60 mg Bromfenex®, Iofed®: Brompheniramine maleate 12 mg and pseudoephedrine hydrochloride 120 mg Elixir: Brofed®: Brompheniramine maleate 4 mg and pseudoephedrine hydrochloride 30 mg per 5 mL Bromfed®: Brompheniramine maleate 2 mg and pseudoephedrine hydrochloride 30 mg per 5 mL Drixoral®: Brompheniramine maleate 2 mg and pseudoephedrine sulfate 30 mg per 5 mL Tablet (Bromfed®): Brompheniramine maleate 4 mg and pseudoephedrine hydrochloride 60 mg |
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