| Pronunciation |
 (bis
a KOE
dil) |
 |
| U.S. Brand Names |
| Bisac-Evac®[OTC]; Bisacodyl Uniserts®; Bisco-Lax®[OTC]; Carter's Little Pills®[OTC]; Clysodrast®; Dacodyl®[OTC]; Deficol®[OTC]; Dulcolax®[OTC]; Feen-A-Mint®[OTC]; Fleet® Laxative [OTC] |
|
| Generic Available |
|
Yes |
|
| Pharmacological Index |
|
Laxative, Stimulant |
|
| Use |
|
Treatment of constipation; colonic evacuation prior to procedures or examination |
|
| Pregnancy Risk Factor |
|
C |
|
| Contraindications |
|
Abdominal pain, obstruction, nausea or vomiting; do not administer bisacodyl tannex enema to children <10 years of age |
|
| Adverse Reactions |
|
<1%: Endocrine & metabolic: Electrolyte and fluid imbalance (metabolic acidosis or alkalosis, hypocalcemia) Gastrointestinal: Mild abdominal cramps, nausea, vomiting, rectal burning |
|
| Drug Interactions |
|
Decreased effect: Milk, antacids; decreased effect of warfarin |
|
| Mechanism of Action |
|
Stimulates peristalsis by directly irritating the smooth muscle of the intestine, possibly the colonic intramural plexus; alters water and electrolyte secretion producing net intestinal fluid accumulation and laxation |
|
| Pharmacodynamics/Kinetics |
|
Onset of action: Oral: 6-10 hours Rectal: 0.25-1 hour Absorption: Oral, rectal: <5% absorbed systemically |
|
| Usual Dosage |
|
Children: Oral: >6 years: 5-10 mg (0.3 mg/kg) at bedtime or before breakfast Rectal suppository: <2 years: 5 mg as a single dose >2 years: 10 mg Adults: Oral: 5-15 mg as single dose (up to 30 mg when complete evacuation of bowel is required) Rectal suppository: 10 mg as single dose Tannex: Enema: 2.5 g in 1000 mL warm water Barium enema: 2.5-5 g in 1000 mL barium suspension Do not administer >10 g within 72-hour period |
|
| Dietary Considerations |
|
Should not be administered within 1 hour of milk, any dairy products, or taking an antacid, to protect the coating; should be administered with glass of water on empty stomach for rapid effect |
|
| Administration |
|
Administer tablets 2 hours prior to, or 4 hours after antacids |
|
| Mental Health: Effects on Mental Status |
|
None reported |
|
| Mental Health: Effects on Psychiatric Treatment |
|
None reported |
|
| Dental Health: Local Anesthetic/Vasoconstrictor Precautions |
|
No information available to require special precautions |
|
| Dental Health: Effects on Dental Treatment |
|
No effects or complications reported |
|
| Patient Information |
|
Onset of action occurs 6-10 hours after oral dose or 15-60 minutes after a rectal dose; swallow tablets whole, do not crush or chew; do not take antacid or milk within 1 hour of taking drug |
|
| Nursing Implications |
|
Administer tablets 2 hours prior to or 4 hours after antacids; increased pH may dissolve the enteric coating leading to GI distress; do not crush enteric coated drug product |
|
| Dosage Forms |
|
Powder, as tannex: 2.5 g packets (50 packet/box) Suppository, rectal: 5 mg, 10 mg Tablet, enteric coated: 5 mg |
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