| Pronunciation |
 (BEN
zoe il peer OKS
ide) |
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| U.S. Brand Names |
| Advanced Formula Oxy® Sensitive Gel [OTC]; Ambi 10®[OTC]; Ben-Aqua®[OTC]; Benoxyl®; Benzac AC® Gel; Benzac AC® Wash; Benzac W® Gel; Benzac W® Wash; 5-Benzagel®; 10-Benzagel®; Benzashave® Cream; BlemErase® Lotion [OTC]; Brevoxyl® Gel; Clear By Design® Gel [OTC]; Clearsil® Maximum Strength [OTC]; Del Aqua-5® Gel; Del Aqua-10® Gel; Desquam-E™ Gel; Desquam-X® Gel; Desquam-X® Wash; Dryox® Gel [OTC]; Dryox® Wash [OTC]; Exact® Cream [OTC]; Fostex® 10% BPO Gel [OTC]; Fostex® 10% Wash [OTC]; Fostex® Bar [OTC]; Loroxide®[OTC]; Neutrogena® Acne Mask [OTC]; Oxy-5® Advanced Formula for Sensitive Skin [OTC]; Oxy-5® Tinted [OTC]; Oxy-10® Advanced Formula for Sensitive Skin [OTC]; Oxy 10® Wash [OTC]; PanOxyl®-AQ; PanOxyl® Bar [OTC]; Perfectoderm® Gel [OTC]; Peroxin A5®; Peroxin A10®; Persa-Gel®; Theroxide® Wash [OTC]; Vanoxide®[OTC] |
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| Generic Available |
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Yes |
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| Pharmacological Index |
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Topical Skin Product; Topical Skin Product, Acne |
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| Use |
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Adjunctive treatment of mild to moderate acne vulgaris and acne rosacea |
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| Pregnancy Risk Factor |
|
C |
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| Adverse Reactions |
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1% to 10%: Dermatologic: Irritation, contact dermatitis, dryness, erythema, peeling, stinging |
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| Drug Interactions |
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Increased toxicity: Benzoyl peroxide potentiates adverse reactions seen with tretinoin |
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| Mechanism of Action |
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Releases free-radical oxygen which oxidizes bacterial proteins in the sebaceous follicles decreasing the number of anaerobic bacteria and decreasing irritating-type free fatty acids |
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| Pharmacodynamics/Kinetics |
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Absorption: ~5% through the skin; gels are more penetrating than creams |
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| Usual Dosage |
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Children and Adults: Topical: Apply sparingly once daily; gradually increase to 2-3 times/day if needed. If excessive dryness or peeling occurs, reduce dose frequency or concentration; if excessive stinging or burning occurs, remove with mild soap and water; resume use the next day. |
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| Dental Health: Local Anesthetic/Vasoconstrictor Precautions |
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No information available to require special precautions |
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| Dental Health: Effects on Dental Treatment |
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No effects or complications reported |
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| Patient Information |
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Shake lotion before using; cleanse and make sure skin is dry before applying; may bleach color from fabrics; may be worn under makeup; improvement should occur within 2 weeks; keep away from eyes, mouth, mucous membranes; expect dryness and peeling; if excessive redness or irritation occurs, discontinue use; avoid excessive sunlight, sun lamps, or other topical medication unless directed by a physician |
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| Nursing Implications |
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Watch for signs of systemic infection; granulation may indicate effectiveness |
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| Dosage Forms |
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Bar: 5% (113 g); 10% (106 g, 113 g) Cream: 5% (18 g, 113.4 g); 10% (18 g, 28 g, 113.4 g) Gel: 2.5% (30 g, 42.5 g, 45 g, 57 g, 60 g, 90 g, 113 g); 5% (42.5 g, 45 g, 60 g, 80 g, 90 g, 113.4 g); 10% (30 g, 42.5 g, 45 g, 56.7 g, 60 g, 90 g, 113.4 g, 120 g); 20% (30 g, 60 g) Liquid: 5% (120 mL, 150 mL, 240 mL); 10% (120 mL, 150 mL, 240 mL) Lotion: 5% (25 mL, 30 mL); 5.5% (25 mL); 10% (12 mL, 29 mL, 30 mL, 60 mL) Mask: 5% (30 mL, 60 mL, 60 g) |
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