Look Up > Drugs > Benzonatate
Benzonatate
Pronunciation
U.S. Brand Names
Generic Available
Pharmacological Index
Use
Pregnancy Risk Factor
Contraindications
Adverse Reactions
Overdosage/Toxicology
Drug Interactions
Mechanism of Action
Pharmacodynamics/Kinetics
Usual Dosage
Monitoring Parameters
Mental Health: Effects on Mental Status
Mental Health: Effects on Psychiatric Treatment
Dental Health: Local Anesthetic/Vasoconstrictor Precautions
Dental Health: Effects on Dental Treatment
Patient Information
Nursing Implications
Dosage Forms
References

Pronunciation
(ben ZOE na tate)

U.S. Brand Names
Tessalon® Perles

Generic Available

No


Pharmacological Index

Antitussive


Use

Symptomatic relief of nonproductive cough


Pregnancy Risk Factor

C


Contraindications

Known hypersensitivity to benzonatate or related compounds (such as tetracaine)


Adverse Reactions

1% to 10%:

Dermatologic: Rash

Gastrointestinal: GI upset

Neuromuscular & skeletal: Numbness in chest

Ocular: Burning sensation in eyes

Respiratory: Nasal congestion


Overdosage/Toxicology

Symptoms of overdose include restlessness, tremor, CNS stimulation. The drug's local anesthetic activity can reduce the patient's gag reflex and, therefore, may contradict the use of ipecac following ingestion, this is especially true when the capsules are chewed.

Gastric lavage may be indicated if initiated early on following an acute ingestion or in comatose patients. The remaining treatment is supportive and symptomatic.


Drug Interactions

No data reported


Mechanism of Action

Tetracaine congener with antitussive properties; suppresses cough by topical anesthetic action on the respiratory stretch receptors


Pharmacodynamics/Kinetics

Onset of action: Therapeutic: Within 15-20 minutes

Duration: 3-8 hours


Usual Dosage

Children >10 years and Adults: Oral: 100 mg 3 times/day or every 4 hours up to 600 mg/day


Monitoring Parameters

Monitor patient's chest sounds and respiratory pattern


Mental Health: Effects on Mental Status

May cause drowsiness


Mental Health: Effects on Psychiatric Treatment

None reported


Dental Health: Local Anesthetic/Vasoconstrictor Precautions

No information available to require special precautions


Dental Health: Effects on Dental Treatment

No effects or complications reported


Patient Information

Take only as prescribed; do not exceed prescribed dose or frequency. Do not break or chew capsule. Maintain adequate hydration (2-3 L/day of fluids unless instructed to restrict fluid intake). Avoid use of other depressants, alcohol, or sleep-inducing medications unless approved by prescriber. You may experience drowsiness, impaired coordination, blurred vision, or increased anxiety (use caution when driving or engaging in tasks requiring alertness until response to drug is known); or upset stomach or nausea (frequent small meals, frequent mouth care, chewing gum, or sucking hard candy may help). Report persistent CNS changes (dizziness, sedation, tremor, or agitation), numbness in chest or feeling of chill, visual changes or burning in eyes, numbness of mouth or difficulty swallowing, or lack of improvement or worsening or condition. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to be pregnant. Consult prescriber if breast-feeding.


Nursing Implications

Change patient position every 2 hours to prevent pooling of secretions in lung; capsules are not to be crushed


Dosage Forms

Capsule: 100 mg


References

Mongan PD and Culling Rd, "Rapid Oral Anesthesia for Awake Intubation," J Clin Anesth, 1992, 4(2):101-5.


Copyright © 1978-2000 Lexi-Comp Inc. All Rights Reserved