|
Pronunciation |
|
(ben
ZOE na
tate) |
|
|
U.S. Brand
Names |
|
Tessalon®
Perles |
|
|
Generic
Available |
|
No |
|
|
Pharmacological Index |
|
Antitussive |
|
|
Use |
|
Symptomatic relief of nonproductive cough |
|
|
Pregnancy Risk
Factor |
|
C |
|
|
Contraindications |
|
Known hypersensitivity to benzonatate or related compounds (such as
tetracaine) |
|
|
Adverse
Reactions |
|
1% to 10%:
Dermatologic: Rash
Gastrointestinal: GI upset
Neuromuscular & skeletal: Numbness in chest
Ocular: Burning sensation in eyes
Respiratory: Nasal congestion |
|
|
Overdosage/Toxicology |
|
Symptoms of overdose include restlessness, tremor, CNS stimulation. The
drug's local anesthetic activity can reduce the patient's gag reflex and,
therefore, may contradict the use of ipecac following ingestion, this is
especially true when the capsules are chewed.
Gastric lavage may be indicated if initiated early on following an acute
ingestion or in comatose patients. The remaining treatment is supportive and
symptomatic. |
|
|
Drug
Interactions |
|
No data reported |
|
|
Mechanism of
Action |
|
Tetracaine congener with antitussive properties; suppresses cough by topical
anesthetic action on the respiratory stretch receptors |
|
|
Pharmacodynamics/Kinetics |
|
Onset of action: Therapeutic: Within 15-20 minutes
Duration: 3-8 hours |
|
|
Usual Dosage |
|
Children >10 years and Adults: Oral: 100 mg 3 times/day or every 4 hours
up to 600 mg/day |
|
|
Monitoring
Parameters |
|
Monitor patient's chest sounds and respiratory pattern |
|
|
Mental Health: Effects
on Mental Status |
|
May cause drowsiness |
|
|
Mental Health:
Effects on Psychiatric
Treatment |
|
None reported |
|
|
Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
|
No information available to require special precautions |
|
|
Dental Health:
Effects on Dental Treatment |
|
No effects or complications reported |
|
|
Patient
Information |
|
Take only as prescribed; do not exceed prescribed dose or frequency. Do not
break or chew capsule. Maintain adequate hydration (2-3 L/day of fluids unless
instructed to restrict fluid intake). Avoid use of other depressants, alcohol,
or sleep-inducing medications unless approved by prescriber. You may experience
drowsiness, impaired coordination, blurred vision, or increased anxiety (use
caution when driving or engaging in tasks requiring alertness until response to
drug is known); or upset stomach or nausea (frequent small meals, frequent mouth
care, chewing gum, or sucking hard candy may help). Report persistent CNS
changes (dizziness, sedation, tremor, or agitation), numbness in chest or
feeling of chill, visual changes or burning in eyes, numbness of mouth or
difficulty swallowing, or lack of improvement or worsening or condition.
Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend
to be pregnant. Consult prescriber if breast-feeding. |
|
|
Nursing
Implications |
|
Change patient position every 2 hours to prevent pooling of secretions in
lung; capsules are not to be crushed |
|
|
Dosage Forms |
|
Capsule: 100 mg |
|
|
References |
|
Mongan PD and Culling Rd, "Rapid Oral Anesthesia for Awake Intubation," J
Clin Anesth, 1992, 4(2):101-5.
|
|
Copyright © 1978-2000 Lexi-Comp Inc. All Rights Reserved
|