Yes

Anticholinergic Agent

Decrease gastrointestinal activity in functional bowel disorders; delay gastric emptying as well as decrease gastric secretion

C

Hypersensitivity to belladonna or any components; glaucoma, elevated intraocular pressure; significant hepatic or renal disease; pulmonary insufficiency

>10%:

Dermatologic: Dry skin

Gastrointestinal: Constipation, dry throat, xerostomia

Respiratory: Dry nose

Miscellaneous: Decreased diaphoresis

1% to 10%:

Dermatologic: Increased sensitivity to light

Endocrine & metabolic: Decreased flow of breast milk, dysphagia

Phenothiazines, amantadine, antiparkinsonian drugs, glutethimide, meperidine, tricyclic antidepressants, antiarrhythmic agents, some antihistamines

Store in tight, light-resistant container at 15°C to 30°C

Belladonna is a mixture of the anticholinergic alkaloids atropine, hyoscyamine, and scopolamine (hyoscine). The belladonna alkaloids act primarily by competitive inhibition of the muscarinic actions of acetylcholine on structures innervated by postganglionic cholinergic neurons and on smooth muscle. The resulting effects include antisecretory activity on exocrine glands and intestinal mucosa and smooth muscle relaxation. The anticholinergic properties of scopolamine and atropine differ in that scopolamine has a more potent activity on the iris, ciliary body, and certain secretory glands; has more potent activity on the heart, intestine, and bronchial muscle, and a more prolonged duration of action; in contrast, hyoscyamine has actions similar to those of atropine, but is more potent in both its central and peripheral effects

Tincture: Oral:

Adults: 0.6-1 mL 3-4 times/day

May cause drowsiness; rare reports of confusion

Concurrent use with psychotropics may produce additive sedation; may decrease the effects of phenothiazines; concurrent use with psychotropics may result in additive anticholinergic side effects (dry mouth, blurred vision, constipation)

No information available to require special precautions

>10% of patients experience dry mouth

May cause drowsiness and blurred vision

Monitor CNS depression; assist patient with ambulation

Tincture: Belladonna alkaloids (principally hyoscyamine and atropine) 0.3 mg/mL with alcohol 65% to 70% (120 mL, 480 mL, 3780 mL)