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Pronunciation |
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(a
TEN oh lole & klor THAL i
done) |
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U.S. Brand
Names |
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Tenoretic® |
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Generic
Available |
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Yes |
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Synonyms |
|
Chlorthalidone and Atenolol |
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|
Pharmacological Index |
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Antihypertensive Agent, Combination |
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Use |
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Treatment of hypertension with a cardioselective beta-blocker and a
diuretic |
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Pregnancy Risk
Factor |
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D |
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Adverse
Reactions |
|
See individual agents |
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Usual Dosage |
|
Adults: Oral: Initial: One (50) tablet once daily, then individualize dose
until optimal dose is achieved |
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Dietary
Considerations |
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Should be administered on empty stomach |
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Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
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No information available to require special precautions |
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Dental Health:
Effects on Dental Treatment |
|
Noncardioselective beta-blockers (ie, propranolol, nadolol) enhance the
pressor response to epinephrine, resulting in hypertension and bradycardia. This
has not been reported for atenolol, a cardioselective beta-blocker. Therefore
local anesthetic with vasoconstrictor can be safely used in patients medicated
with atenolol. Many nonsteroidal anti-inflammatory drugs such as ibuprofen and
indomethacin can reduce the hypotensive effect of beta-blockers after 3 or more
weeks of therapy with the NSAID. Short-term NSAID use (ie, 3 days) requires no
special precautions in patients taking beta-blockers. |
|
|
Patient
Information |
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See individual agents. Pregnancy/breast-feeding precautions: Inform
prescriber if you are or intend to be pregnant. Consult prescriber if
breast-feeding. |
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Nursing
Implications |
|
May contain povidone as inactive ingredient |
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|
Dosage Forms |
|
Tablet:
100: Atenolol 100 mg and chlorthalidone 25 mg |
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References |
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Foster CA and Aston SJ,
"Propranolol-Epinephrine Interaction: A Potential Disaster," Plast Reconstr
Surg, 1983, 72(1):74-8.
Wong DG, Spence JD, Lamki L, et al,
"Effect of Nonsteroidal Anti-inflammatory Drugs on Control of Hypertension of Beta-Blockers and Diuretics,"
Lancet, 1986, 1(8488):997-1001.
Wynn RL,
"Dental Nonsteroidal Anti-inflammatory Drugs and Prostaglandin-Based Drug Interactions-Part Two,"
Gen Dent, 1992, 40(2):104, 106, 108.
Wynn RL, "Epinephrine Interactions With Beta-Blockers," Gen Dent,
1994, 42(1):16, 18. |
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