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Pronunciation |
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(AS
pir in & me proe BA
mate) |
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U.S. Brand
Names |
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Equagesic® |
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Generic
Available |
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Yes |
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Synonyms |
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Meprobamate and Aspirin |
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Pharmacological Index |
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Antianxiety Agent, Miscellaneous |
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Use |
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Adjunct to treatment of skeletal muscular disease in patients exhibiting
tension and/or anxiety |
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Restrictions |
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C-IV |
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Pregnancy Risk
Factor |
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D |
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Contraindications |
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Acute intermittent porphyria; hypersensitivity to aspirin, meprobamate, or
any component |
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Adverse
Reactions |
|
See individual agents |
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Drug
Interactions |
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Increased effect: CNS depressant medications have additive
effects |
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Usual Dosage |
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Oral: 1 tablet 3-4 times/day |
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Dietary
Considerations |
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May be administered with food to minimize GI upset |
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Mental Health: Effects
on Mental Status |
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Sedation is common |
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Mental Health:
Effects on Psychiatric
Treatment |
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May cause leukopenia; use caution with clozapine and carbamazepine; may
displace valproic acid from binding sites resulting in an increase of unbound
drug; monitor for toxicity; meprobamate is a CNS depressant; monitor for
additive effects with concurrent psychotropic use |
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Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
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No information available to require special precautions |
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Dental Health:
Effects on Dental Treatment |
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Avoid aspirin, if possible, for 1 week prior to surgery because of the
possibility of postoperative bleeding
Elderly are a high-risk population for adverse effects from nonsteroidal
anti-inflammatory agents. As much as 60% of elderly with GI complications to
NSAIDs can develop peptic ulceration and/or hemorrhage asymptomatically. Also,
concomitant disease and drug use contribute to the risk for GI adverse effects.
Use lowest effective dose for shortest period possible. Consider renal function
decline with age. Use with caution in patients with history of asthma
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Patient
Information |
|
See individual agents. Pregnancy/breast-feeding precautions: Inform
prescriber if you are or intend to be pregnant. Consult prescriber if
breast-feeding. |
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Dosage Forms |
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Tablet: Aspirin 325 mg and meprobamate 200 mg |
|
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References |
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Desjardins PJ, Cooper SA, Gallegos TL, et al,
"The Relative Analgesic Efficacy of Propiram Fumarate, Codeine Aspirin, and Placebo in Post-Impaction Dental Pain,"
J Clin Pharmacol, 1984, 24(1):35-42.
Forbes JA, Butterworth GA, Burchfield WH, et al,
"Evaluation of Ketorolac, Aspirin, and an Acetaminophen-Codeine Combination in Postoperative Oral Surgery Pain,"
Pharmacotherapy, 1990, 10(6 Pt 2):77S-93S.
Forbes JA, Keller CK, Smith JW, et al,
"Analgesic Effect of Naproxen Sodium, Codeine, a Naproxen-Codeine Combination and Aspirin on the Postoperative Pain of Oral Surgery,"
Pharmacotherapy, 1986, 6(5):211-8. |
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