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Look Up > Drugs > Aspirin and Meprobamate
Aspirin and Meprobamate
Pronunciation
U.S. Brand Names
Generic Available
Synonyms
Pharmacological Index
Use
Restrictions
Pregnancy Risk Factor
Contraindications
Adverse Reactions
Drug Interactions
Usual Dosage
Dietary Considerations
Mental Health: Effects on Mental Status
Mental Health: Effects on Psychiatric Treatment
Dental Health: Local Anesthetic/Vasoconstrictor Precautions
Dental Health: Effects on Dental Treatment
Patient Information
Dosage Forms
References

Pronunciation
(AS pir in & me proe BA mate)

U.S. Brand Names
Equagesic®

Generic Available

Yes


Synonyms
Meprobamate and Aspirin

Pharmacological Index

Antianxiety Agent, Miscellaneous


Use

Adjunct to treatment of skeletal muscular disease in patients exhibiting tension and/or anxiety


Restrictions

C-IV


Pregnancy Risk Factor

D


Contraindications

Acute intermittent porphyria; hypersensitivity to aspirin, meprobamate, or any component


Adverse Reactions

See individual agents


Drug Interactions

Increased effect: CNS depressant medications have additive effects


Usual Dosage

Oral: 1 tablet 3-4 times/day


Dietary Considerations

May be administered with food to minimize GI upset


Mental Health: Effects on Mental Status

Sedation is common


Mental Health: Effects on Psychiatric Treatment

May cause leukopenia; use caution with clozapine and carbamazepine; may displace valproic acid from binding sites resulting in an increase of unbound drug; monitor for toxicity; meprobamate is a CNS depressant; monitor for additive effects with concurrent psychotropic use


Dental Health: Local Anesthetic/Vasoconstrictor Precautions

No information available to require special precautions


Dental Health: Effects on Dental Treatment

Avoid aspirin, if possible, for 1 week prior to surgery because of the possibility of postoperative bleeding

Elderly are a high-risk population for adverse effects from nonsteroidal anti-inflammatory agents. As much as 60% of elderly with GI complications to NSAIDs can develop peptic ulceration and/or hemorrhage asymptomatically. Also, concomitant disease and drug use contribute to the risk for GI adverse effects. Use lowest effective dose for shortest period possible. Consider renal function decline with age. Use with caution in patients with history of asthma


Patient Information

See individual agents. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to be pregnant. Consult prescriber if breast-feeding.


Dosage Forms

Tablet: Aspirin 325 mg and meprobamate 200 mg


References

Desjardins PJ, Cooper SA, Gallegos TL, et al, "The Relative Analgesic Efficacy of Propiram Fumarate, Codeine Aspirin, and Placebo in Post-Impaction Dental Pain," J Clin Pharmacol, 1984, 24(1):35-42.

Forbes JA, Butterworth GA, Burchfield WH, et al, "Evaluation of Ketorolac, Aspirin, and an Acetaminophen-Codeine Combination in Postoperative Oral Surgery Pain," Pharmacotherapy, 1990, 10(6 Pt 2):77S-93S.

Forbes JA, Keller CK, Smith JW, et al, "Analgesic Effect of Naproxen Sodium, Codeine, a Naproxen-Codeine Combination and Aspirin on the Postoperative Pain of Oral Surgery," Pharmacotherapy, 1986, 6(5):211-8.


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