No

Antihemophilic Agent

Management of hemophilia A in patients whom a deficiency in factor VIII has been demonstrated

C

Hypersensitivity to mouse protein (Monoclate-P®, Hemofil® M, Method M, Monoclonal Purified) and antihemophilic factor (human); Method M and Monoclonal Purified contain trace amounts of mouse protein

Administer with caution using universal precautions

<1% (Limited to important or life-threatening symptoms): Flushing, tachycardia, tightness in neck or chest, slight decrease in BP, headache, nausea, vomiting, paresthesia, allergic vasomotor reactions

I.V.: Individualize dosage based on coagulation studies performed prior to and during treatment at regular intervals. One AHF unit is the activity present in 1 mL of normal pooled human plasma; dosage should be adjusted to actual vial size currently stocked in the pharmacy.

Formula to approximate percentage increase in plasma antihemophilic factor:

Units required = desired level increase (desired level - actual level) x plasma volume (mL)

Total blood volume (mL blood/kg) = 70 mL/kg (adults); 80 mL/kg (children).

Plasma volume = total blood volume (mL) x [1 - Hct (in decimals)]

ie, for a 70 kg adult with a Hct = 40% : plasma volume = [70 kg x 70 mL/kg] x [1 - 0.4] = 2940 mL

To calculate number of units of factor VIII needed to increase level to desired range (highly individualized and dependent on patient's condition):

Number of units = desired level increase [desired level - actual level] x plasma volume (in mL)

ie, for a 100% level in the above patient who has an actual level of 20% the number of units needed = [1 (for a 100% level) - 0.2] x 2940 mL = 2352 units

No information available to require special precautions

No effects or complications reported

Can only be administered I.V. Alert medical or dental personnel of your need for this factor. Immediately report signs of hypersensitivity reaction (eg, hives, tight feeling in chest or wheezing, dizziness, headache, or difficulty breathing). Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to be pregnant. Consult prescriber if breast-feeding.

Monitor heart rate (before and during I.V. administration); plasma antihemophilic factor levels prior to and during treatment

Injection: 250 units, 500 units, 1000 units