Yes

Anticholinergic Agent

Adjunctive treatment of peptic ulcer

C

Narrow-angle glaucoma, obstructive GI tract or uropathy, severe ulcerative colitis, myasthenia gravis, intestinal atony, hepatic disease, hypersensitivity

Drug-induced heatstroke can develop in hot or humid climates

>10%:

Cardiovascular: Palpitations

Dermatologic: Dry skin

Gastrointestinal: Constipation, dry throat, xerostomia

Respiratory: Dry nose

Miscellaneous: Diaphoresis (decreased)

1% to 10%:

Endocrine & metabolic: Decreased flow of breast milk

Gastrointestinal: Decreased salivary secretion

<1%: Orthostatic hypotension, confusion, drowsiness, headache, loss of memory, fatigue, rash, bloated feeling, nausea, vomiting, decreased urination, weakness, increased intraocular pain, blurred vision, increased sensitivity to light

Symptoms of overdose include blurred vision, dysphagia, urinary retention, tachycardia, hypertension

Anisotropine toxicity is caused by strong binding of the drug to cholinergic receptors. Anticholinesterase inhibitors reduce acetylcholinesterase, the enzyme that breaks down acetylcholine and thereby allows acetylcholine to accumulate and compete for receptor binding with this offending anticholinergic. For an overdose with severe life-threatening symptoms, physostigmine 1-2 mg (0.5 mg or 0.02 mg/kg for children) S.C. or I.V., slowly may be given to reverse these effects.

No data reported

Blocks the action of acetylcholine at parasympathetic sites in smooth muscle, secretory glands, and the CNS; increases cardiac output, dries secretions, antagonizes histamine and serotonin

Absorption: Poor (~10%) from GI tract

Elimination: Principally in urine as unchanged drug and metabolites

Adults: Oral: 50 mg 3 times/day

Administer 30-60 minutes before meals

Monitor patient's vital signs and I & O

Rarely may produce confusion and memory impairment

Anticholinergic effects may be exacerbated by psychotropic with anticholinergic activity (benztropine, TCAs)

No information available to require special precautions

>10% of patients experience dry mouth; orthostatic hypotension possible

Dry mouth can be relieved by sugarless gum or hard candy; drink plenty of fluids

Monitor vital signs and I & O

Tablet, as methylbromide: 50 mg