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Pronunciation |
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(am
LOE di peen & ben AY ze
pril) |
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U.S. Brand
Names |
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Lotrel® |
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Generic
Available |
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No |
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Synonyms |
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Benazepril and Amlodipine |
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Pharmacological Index |
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Antihypertensive Agent, Combination |
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Use |
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Treatment of hypertension |
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Pregnancy Risk
Factor |
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C/D (2nd and 3rd trimesters) |
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Mechanism of
Action |
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The mechanism through which benazepril lowers blood pressure is believed to
be primarily suppression of the renin-angiotensin-aldosterone system, benazepril
has an antihypertensive effect even in patients with low-renin hypertension;
amlodipine is a dihydropyridine calcium antagonist that inhibits the
transmembrane influx of calcium ions into vascular smooth muscle and cardiac
muscle; amlodipine is a peripheral arterial vasodilator that acts directly on
vascular smooth muscle to cause a reduction in peripheral vascular resistance
and reduction in blood pressure |
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Pharmacodynamics/Kinetics |
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Absorption: Not influenced by the presence of food in the GI tract; food
effects on absorption have not been studied
Amlodipine: 64% to 90%
Benazepril: 37%
Time to peak (plasma):
Amlodipine: 6-12 hours
Benazepril: 0.5-2 hours |
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Usual Dosage |
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Adults: Oral: 1 capsule daily |
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Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
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No information available to require special precautions |
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Dental Health:
Effects on Dental Treatment |
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Calcium channel blockers (CCBs) cause gingival hyperplasia in approximately
1% of the patients. There have been fewer reports with amlodipine than with
other CCBs. The hyperplasia will usually disappear with cessation of drug
therapy. Consultation with physician is suggested. |
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Patient
Information |
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See individual agents. Pregnancy/breast-feeding precautions: Inform
prescriber if you are or intend to be pregnant. Consult prescriber if
breast-feeding. |
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Dosage Forms |
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Capsule:
Amlodipine 5 mg and benazepril hydrochloride 10 mg
Amlodipine 5 mg and benazepril hydrochloride 20 mg |
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References |
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Wynn RL,
"An Update on Calcium Channel Blocker-Induced Gingival Hyperplasia," Gen
Dent, 1995, 43(3):218-22.
Wynn RL, "Calcium Channel Blockers and Gingival Hyperplasia," Gen
Dent, 1991, 39(4):240-3. |
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