Yes

Diuretic, Combination

Potassium-sparing diuretic; antihypertensive

B

See individual agents

Adults: Oral: Start with 1 tablet/day, then may be increased to 2 tablets/day if needed; usually given in a single dose

May be administered with food

Amiloride may cause hyperkalemia, the EKG manifestations of which include peaked T waves, QRS prolongation, and cardiac conduction abnormalities. Thiazide diuretics are effective first-line therapeutic agents in the management of hypertension and have proven to be of benefit in terms of cardiovascular outcome. The combination of amiloride and hydrochlorothiazide may act together to lower blood pressure and limit diuretic-induced changes in plasma potassium. The benefits of thiazide diuretics in the treatment of hypertension is established and compares well with other first-line therapeutic agents.

No information available to require special precautions

No effects or complications reported

See individual agents. Breast-feeding precautions: Do not breast-feed.

Monitor blood pressure, serum electrolytes, renal function

Tablet: Amiloride hydrochloride 5 mg and hydrochlorothiazide 50 mg